The HLA system and the clinical response to treatment with chlorpromazine

E. Smeraldi, L. Bellodi, E. Sacchetti, C. L. Cazzullo

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A group of 33 schizophrenic patients were typed for HLA SD antigens and their qualitative clinical responses to chlorpromazine therapy determined. A highly significant positive correlation was found between response to chlorpromazine and HLA A1 positive, while HLA A2 positive subjects showed a significant negative correlation to chlorpromazine treatment. In a second group of 17 patients the clinical responses to chlorpromazine were evaluated quantitatively, by WPRS, in HLA A1 positive and HLA A1 negative patients. There were no pre treatment differences in the scores. After treatment the scores of positive patients were significantly lower, indicating that they responded to a greater degree. Since the frequency of HLA A1 in hebephrenic patients is higher than that in other schizophrenics this may explain the authors' earlier finding that hebephrenics, as a group, respond better to chlorpromazine than do other schizophrenics.

Original languageEnglish
Pages (from-to)486-489
Number of pages4
JournalBritish Journal of Psychiatry
Issue number11
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)


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