The homeostasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients

Giovanna Fattovich, Loredana Covolo, Michela Pasino, Eleonora Perini, Luigi Rossi, Giorgio Brocco, Maria Guido, Chiara Cristofori, Caterina Belotti, Massimo Puoti, Giovanni Battista Gaeta, Teresa Santantonio, Giovanni Raimondo, Raffaele Bruno, Eliseo Minola, Francesco Negro, Francesco Donato

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To investigate the independent association between the homeostasis model assessment of the insulin resistance (HOMA-IR) score and rapid virological response (RVR) and sustained virological response (SVR) in chronic hepatitis C (CHC).Methods: Observational prospective cohort study of 412 CHC patients [59% males; mean age 45 years; genotype 1 (44%), 2 (32%), 3 (19%) and 4 (5%)] treated with pegylated interferon α plus ribavirin.Results: A HOMA-IR ≥2.0 was present in 49% and a metabolic syndrome in 4% of patients. By multivariate analysis, independent predictors of SVR were the lack of advanced fibrosis (≥F3) in genotype 1 and a lower body mass index in genotype 3 patients. In the subgroup of patients in whom HCV-RNA was evaluated at week 4 (n=281), independent predictors of RVR were HCV-RNA

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalLiver International
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Hepatitis C virus genotype
  • Homeostasis model assessment of insulin resistance
  • Metabolic syndrome
  • Rapid virological response
  • Sustained virological response
  • Treatment-naïve patients

ASJC Scopus subject areas

  • Hepatology

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