The hot IVGTT two-compartment minimal model

Indexes of glucose effectiveness and insulin sensitivity

Paolo Vicini, Andrea Caumo, Claudio Cobelli

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume273
Issue number5 36-5
Publication statusPublished - 1997

Fingerprint

Glucose Tolerance Test
Insulin Resistance
Insulin
Glucose
Plasmas
Isotopes
Metabolism
Kinetics

Keywords

  • Intravenous glucose tolerance test
  • Plasma clearance rate
  • Tracer kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Physiology (medical)

Cite this

The hot IVGTT two-compartment minimal model : Indexes of glucose effectiveness and insulin sensitivity. / Vicini, Paolo; Caumo, Andrea; Cobelli, Claudio.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 273, No. 5 36-5, 1997.

Research output: Contribution to journalArticle

@article{2afe0aa97b1944aea328ecac4ae26d29,
title = "The hot IVGTT two-compartment minimal model: Indexes of glucose effectiveness and insulin sensitivity",
abstract = "A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.",
keywords = "Intravenous glucose tolerance test, Plasma clearance rate, Tracer kinetics",
author = "Paolo Vicini and Andrea Caumo and Claudio Cobelli",
year = "1997",
language = "English",
volume = "273",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "5 36-5",

}

TY - JOUR

T1 - The hot IVGTT two-compartment minimal model

T2 - Indexes of glucose effectiveness and insulin sensitivity

AU - Vicini, Paolo

AU - Caumo, Andrea

AU - Cobelli, Claudio

PY - 1997

Y1 - 1997

N2 - A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.

AB - A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.

KW - Intravenous glucose tolerance test

KW - Plasma clearance rate

KW - Tracer kinetics

UR - http://www.scopus.com/inward/record.url?scp=0030659571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030659571&partnerID=8YFLogxK

M3 - Article

VL - 273

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 5 36-5

ER -