Abstract
A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Endocrinology and Metabolism |
| Volume | 273 |
| Issue number | 5 36-5 |
| Publication status | Published - 1997 |
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Keywords
- Intravenous glucose tolerance test
- Plasma clearance rate
- Tracer kinetics
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Physiology (medical)
Cite this
The hot IVGTT two-compartment minimal model : Indexes of glucose effectiveness and insulin sensitivity. / Vicini, Paolo; Caumo, Andrea; Cobelli, Claudio.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 273, No. 5 36-5, 1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The hot IVGTT two-compartment minimal model
T2 - Indexes of glucose effectiveness and insulin sensitivity
AU - Vicini, Paolo
AU - Caumo, Andrea
AU - Cobelli, Claudio
PY - 1997
Y1 - 1997
N2 - A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.
AB - A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993] to describe intravenous glucose tolerance test (IVGTT) labeled (hereafter hot) glucose kinetics. This model, at variance with the one-compartment minimal model (1CMM), allows the estimation of a plausible profile of glucose production. The aim of this study is to show that the 2CMM also allows the assessment of insulin sensitivity (S(I)/(2*)), glucose effectiveness (S(G)/(2*)), and plasma clearance rate (PCR). The 2CMM was identified on stable-isotope IVGTTs performed in normal subjects (n = 14). Results were (means ± SE) S(G)/(2*) = 0.85 ± 0.14 ml · kg-1 · min-1, PCR = 2.02 ± 0.14 ml · kg-1 · min-1, and S(I)/(2*) = 13.83 ± 2.54 x 10-2 ml · kg-1 · min-1 · μU-1 · ml. The 1CMM was also identified; glucose effectiveness and insulin sensitivity indexes were S(G)/*V = 1.36 ± 0.08 ml · kg-1 · min-1 and S(I)/*V = 12.98 ± 2.21 x 10-2 ml · kg-1. min-1 · μU-1 · ml, respectively, where V is the 1CMM glucose distribution volume. S(G)/*V was lower than PCR and higher than S(G)/(2*) and did not correlate with either [r = 0.45 (NS) and r = 0.50 (NS), respectively], whereas S(I)/*V was not different from and was correlated with S(I)/(2*) (r = 0.95; P <0.001). S(G)/* compares well (r = 0.78; P <0.001) with PCR normalized by the 2CMM total glucose distribution volume. In conclusion, the 2CMM is a powerful tool to assess glucose metabolism in vivo.
KW - Intravenous glucose tolerance test
KW - Plasma clearance rate
KW - Tracer kinetics
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UR - http://www.scopus.com/inward/citedby.url?scp=0030659571&partnerID=8YFLogxK
M3 - Article
VL - 273
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 5 36-5
ER -