The hu-PBL-SCID mouse in human lymphocyte function and lymphomagenesis studies

Achievements and caveats

Alberto Amadori, Arianna Veronesi, Vincenzo Coppola, Stefano Indraccolo, Marta Mion, Luigi Chieco-Bianchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The chance isolation of a mouse strain mutant that shows a complete deficiency in both the humoral and cellular immunity compartments has opened new perspectives in numerous fields of medicine and biology, including oncology, hematology and immunology. However, the original concept that the severe combined immunodeficiency mouse might behave as a 'living vessel', and allow experimental approaches that are precluded in man by technical and ethical constraints, has not fully withstood the test of time. At present, despite the body of important results achieved in the past few years, the use of this model in some areas is somewhat deregulated; no standard protocols are available, and some critical variables that could affect experimental results are not always under control. In this article, we have focused on the use of the SCID mouse reconstituted with human mature lymphoid cells in immunological studies, and tried to enucleate, in the array of existing experimental work, some basic concepts that might favor more judicious and appropriate approaches to the use of this important experimental model.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalSeminars in Immunology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 1996

Fingerprint

Mutant Strains Mice
Severe Combined Immunodeficiency
SCID Mice
Hematology
Humoral Immunity
Allergy and Immunology
Cellular Immunity
Theoretical Models
Medicine
Lymphocytes

Keywords

  • AIDS
  • HIV
  • Immune response
  • SCID mouse
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

The hu-PBL-SCID mouse in human lymphocyte function and lymphomagenesis studies : Achievements and caveats. / Amadori, Alberto; Veronesi, Arianna; Coppola, Vincenzo; Indraccolo, Stefano; Mion, Marta; Chieco-Bianchi, Luigi.

In: Seminars in Immunology, Vol. 8, No. 4, 08.1996, p. 249-254.

Research output: Contribution to journalArticle

Amadori, Alberto ; Veronesi, Arianna ; Coppola, Vincenzo ; Indraccolo, Stefano ; Mion, Marta ; Chieco-Bianchi, Luigi. / The hu-PBL-SCID mouse in human lymphocyte function and lymphomagenesis studies : Achievements and caveats. In: Seminars in Immunology. 1996 ; Vol. 8, No. 4. pp. 249-254.
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