the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a

Roberto Doliana, Isabella Bellina, Francesco Bucciotti, Maurizio Mongiat, Roberto Perris, Alfonso Colombatti

Research output: Contribution to journalArticle

Abstract

We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalFEBS Letters
Volume417
Issue number1
DOIs
Publication statusPublished - Nov 3 1997

Keywords

  • α Chain
  • Human laminin
  • Tissue expression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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