L'alfa-Fetoproteina Umana

Translated title of the contribution: The human alpha fetoprotein

Carlo Vergani, Marco Pizzolato, Nicola Dioguardi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Alpha fetoprotein (AFP) is a normal constituent of fetal serum which attains maximum concentration at approximately 13 weeks of gestation. This protein disappears gradually by the time of birth. However, recently, it has been detected in trace amounts by radioimmunologic method in normal adults sera too. Measurable amounts of AFP are found by immunoprecipitation techniques in approximately 50% of patients with primary liver cancer and in few cases of gonadal teratoma, gastric carcinoma and metastatic cancer in liver. AFP is therefore a tumor antigen mainly associated with hepatocellular carcinoma. Its detection is a helpful diagnostic tool. Physico-chemical and biological properties of AFP are reviewed and electrophoretic and immunologic techniques for its investigation are described.

Original languageItalian
Pages (from-to)486-529
Number of pages44
JournalLa Ricerca in Clinica e in Laboratorio
Volume1
Issue number1-4
DOIs
Publication statusPublished - Mar 1971

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alpha-Fetoproteins
Liver Neoplasms
Liver
Immunologic Techniques
Teratoma
Neoplasm Antigens
Serum
Immunoprecipitation
Hepatocellular Carcinoma
Stomach
Parturition
Carcinoma
Pregnancy
human AFP protein
Proteins

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

L'alfa-Fetoproteina Umana. / Vergani, Carlo; Pizzolato, Marco; Dioguardi, Nicola.

In: La Ricerca in Clinica e in Laboratorio, Vol. 1, No. 1-4, 03.1971, p. 486-529.

Research output: Contribution to journalArticle

Vergani, Carlo ; Pizzolato, Marco ; Dioguardi, Nicola. / L'alfa-Fetoproteina Umana. In: La Ricerca in Clinica e in Laboratorio. 1971 ; Vol. 1, No. 1-4. pp. 486-529.
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