L'alfa-Fetoproteina Umana

Translated title of the contribution: The human alpha fetoprotein

Carlo Vergani, Marco Pizzolato, Nicola Dioguardi

Research output: Contribution to journalArticlepeer-review


Alpha fetoprotein (AFP) is a normal constituent of fetal serum which attains maximum concentration at approximately 13 weeks of gestation. This protein disappears gradually by the time of birth. However, recently, it has been detected in trace amounts by radioimmunologic method in normal adults sera too. Measurable amounts of AFP are found by immunoprecipitation techniques in approximately 50% of patients with primary liver cancer and in few cases of gonadal teratoma, gastric carcinoma and metastatic cancer in liver. AFP is therefore a tumor antigen mainly associated with hepatocellular carcinoma. Its detection is a helpful diagnostic tool. Physico-chemical and biological properties of AFP are reviewed and electrophoretic and immunologic techniques for its investigation are described.

Translated title of the contributionThe human alpha fetoprotein
Original languageItalian
Pages (from-to)486-529
Number of pages44
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1-4
Publication statusPublished - Mar 1971

ASJC Scopus subject areas

  • Clinical Biochemistry


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