Astrocytes associated with β-amyloid (Aβ) accumulate in senile plaques of Alzheimer's disease (AD). To investigate the biological effects of Aβ/astrocyte interaction, we examined chemokine production by the human astrocytoma cell line U373MG stimulated with Aβ peptides. Northern blot analysis and specific immunoassays demonstrate that Aβ [1-42] and Aβ [25-35] induce mRNA expression and release of monocyte chemotactic protein (MCP)-1 but not of γ-interferon inducible protein (IP)-10 by U373MG cells. The observation that Aβ induces astrocyte production of the potent microglia chemoattractant MCP-1 contributes to understanding mechanism of damage exerted by Aβ in AD senile plaques. Copyright (C) 2000 Elsevier Science Ireland Ltd.
- γ-Interferon inducible protein (IP)-10
- Alzheimer's disease
- Monocyte chemotactic protein (MCP)-1
ASJC Scopus subject areas