The human gene coding for HCN2, a pacemaker channel of the heart

T. Vaccari, A. Moroni, M. Rocchi, L. Gorza, M. E. Bianchi, M. Beltrame, D. Difrancesco

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, underlying 'pacemaker' currents (I(f)/I(h)), are involved in pacemaker activity of cardiac sinoatrial node myocytes and central neurons. Several cDNAs deriving from four different genes were recently identified which code for channels characterized by six transmembrane domains and a cyclic nucleotide binding domain. We report here the identification of the human HCN2 gene and show that its functional expression in a human kidney cell line generates a current with properties similar to the native pacemaker f-channel of the heart. The hHCN2 gene maps to the telomeric region of chromosome 19, band p13.3. This is the first identification of a genetic locus coding for an HCN channel. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalBBA - Gene Structure and Expression
Volume1446
Issue number3
DOIs
Publication statusPublished - Sep 3 1999

Keywords

  • Cardiac pacemaker channel
  • Chromosome 19
  • Hyperpolarization-activated channel

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Structural Biology
  • Biophysics

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