The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

Giorgio La Nasa, Roberto Littera, Franco Locatelli, Sara Lai, Francesco Alba, Giovanni Caocci, Daniela Lisini, Sonia Nesci, Adriana Vacca, Eugenia Piras, Maria Ester Bernardo, Alessandra Di Cesare-Merlone, Sandro Orrù, Carlo Carcassi

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalBritish Journal of Haematology
Volume139
Issue number2
DOIs
Publication statusPublished - Oct 2007

Keywords

  • 14-basepair polymorphism
  • Acute graft-versus-host disease
  • Bone marrow transplantation
  • Human leucocyte antigen-G
  • Thalassaemia

ASJC Scopus subject areas

  • Hematology

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