The human lymphocyte as a model of β-adrenoceptor reculation in aging and disease

A. Basso, G. Rossolini, C. Viticchi, A. Zaia, L. Plantanelli

Research output: Contribution to journalArticle

Abstract

Extensive experimental evidence suggests that human lymphocytes may model the behavior of other tissues as far as β-adrenoceptor characteristics are concerned. In fact, although lymphocytes bear only β2-adrenoceptor subtype, they may mirror other tissues in various physiological and pathological conditions. In the present paper examples are given demonstrating receptor regulations after drug or surgical stimulus. Age-related changes have also been taken into account. Treatment with β1-selective β-blockers without or with intrinsic sympathomimetic activity induces, respectively, up- or down-regulation of β-adrenoceptors of lymphocytes in agreement with other tissues, as suggested by clinical findings. Data on the influence of thyroidectomy are also in agreement with clinical observations and animal experimental findings on other tissues. Preliminary results on old subjects also suggest a possible role of the human lymphocyte in modelling other tissues or organs in relation to aging processes. The clinical application could be of paramount importance due to the impossibility to directly monitor the receptor status in most of human tissues.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalArchives of Gerontology and Geriatrics
Volume15
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1992

Keywords

  • human lymphocytes
  • model of aging
  • thyroidectomy
  • β-adrenoceptors
  • β-blockers

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)
  • Medicine(all)

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