The human phosphatase interactome: An intricate family portrait

Francesca Sacco, Livia Perfetto, Luisa Castagnoli, Gianni Cesareni

Research output: Contribution to journalArticlepeer-review

Abstract

The concerted activities of kinases and phosphatases modulate the phosphorylation levels of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are still missing a holistic picture representing, at a proteome level, the functional relationships between kinases, phosphatases and their substrates. Here we focus on phosphatases and we review and integrate the available information that helps to place the members of the protein phosphatase superfamilies into the human protein interaction network. In addition we show how protein interaction domains and motifs, either covalently linked to the phosphatase domain or in regulatory/adaptor subunits, play a prominent role in substrate selection.

Original languageEnglish
Pages (from-to)2732-2739
Number of pages8
JournalFEBS Letters
Volume586
Issue number17
DOIs
Publication statusPublished - Aug 14 2012

Keywords

  • Human phosphatome
  • Phosphatase family classification
  • Substrate recognition specificity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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