The human polyomaviruses KI and WU

Virological background and clinical implications

Muhammed Babakir-Mina, Massimo Ciccozzi, Carlo Federico Perno, Marco Ciotti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In 2007, two novel polyomaviruses KI and WU were uncovered in the respiratory secretions of children with acute respiratory symptoms. Seroepidemiological studies showed that infection by these viruses is widespread in the human population. Following these findings, different biological specimens and body compartments have been screened by real-time PCR in the attempt to establish a pathogenetic role for KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) in human diseases. Although both viruses have been found mainly in respiratory tract samples of immunocompromised patients, a clear causative link with the respiratory disease has not been established. Indeed, the lack of specific clinical or radiological findings, the frequent co-detection with other respiratory pathogens, the detection in subjects without signs or symptoms of respiratory disease, and the variability of the viral loads measured did not allow drawing a definitive conclusion. Prospective studies carried out on a large sample size including both immunocompromised and immunocompetent patients with and without respiratory symptoms are needed. Standardized quantitative real-time PCR methods, definition of a clear clinical cutoff value, timing in the collection of respiratory samples, are also crucial to understand the pathogenic role, if any, of KIPyV and WUPyV in human pathology.

Original languageEnglish
Pages (from-to)746-754
Number of pages9
JournalAPMIS
Volume121
Issue number8
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Polyomavirus
Immunocompromised Host
Real-Time Polymerase Chain Reaction
Respiratory Signs and Symptoms
Seroepidemiologic Studies
Virus Diseases
Viral Load
Respiratory System
Sample Size
Prospective Studies
Pathology
Viruses
Population

Keywords

  • KIPyV
  • Polyomaviruses
  • Real-time PCR
  • Viral load
  • WUPyV

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology and Allergy

Cite this

The human polyomaviruses KI and WU : Virological background and clinical implications. / Babakir-Mina, Muhammed; Ciccozzi, Massimo; Perno, Carlo Federico; Ciotti, Marco.

In: APMIS, Vol. 121, No. 8, 08.2013, p. 746-754.

Research output: Contribution to journalArticle

Babakir-Mina, Muhammed ; Ciccozzi, Massimo ; Perno, Carlo Federico ; Ciotti, Marco. / The human polyomaviruses KI and WU : Virological background and clinical implications. In: APMIS. 2013 ; Vol. 121, No. 8. pp. 746-754.
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