The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain

Luca Tamagnone, Juha Partanen, Elina Armstrong, Jerzy Lasota, Kinya Ohgami, Tetsushi Tazunoki, Sal LaForgia, Kay Huebner, Kari Alitalo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined.

Original languageEnglish
Pages (from-to)2009-2014
Number of pages6
JournalOncogene
Volume8
Issue number7
Publication statusPublished - Jul 1993

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Protein-Tyrosine Kinases
Catalytic Domain
Complementary DNA
Proteins
K562 Cells
Receptor Protein-Tyrosine Kinases
Human Chromosomes
Membrane Potentials
Open Reading Frames
Genes
Leukemia
Amino Acids
Polymerase Chain Reaction
Messenger RNA

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Tamagnone, L., Partanen, J., Armstrong, E., Lasota, J., Ohgami, K., Tazunoki, T., ... Alitalo, K. (1993). The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. Oncogene, 8(7), 2009-2014.

The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. / Tamagnone, Luca; Partanen, Juha; Armstrong, Elina; Lasota, Jerzy; Ohgami, Kinya; Tazunoki, Tetsushi; LaForgia, Sal; Huebner, Kay; Alitalo, Kari.

In: Oncogene, Vol. 8, No. 7, 07.1993, p. 2009-2014.

Research output: Contribution to journalArticle

Tamagnone, L, Partanen, J, Armstrong, E, Lasota, J, Ohgami, K, Tazunoki, T, LaForgia, S, Huebner, K & Alitalo, K 1993, 'The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain', Oncogene, vol. 8, no. 7, pp. 2009-2014.
Tamagnone, Luca ; Partanen, Juha ; Armstrong, Elina ; Lasota, Jerzy ; Ohgami, Kinya ; Tazunoki, Tetsushi ; LaForgia, Sal ; Huebner, Kay ; Alitalo, Kari. / The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. In: Oncogene. 1993 ; Vol. 8, No. 7. pp. 2009-2014.
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