The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain

Luca Tamagnone, Juha Partanen, Elina Armstrong, Jerzy Lasota, Kinya Ohgami, Tetsushi Tazunoki, Sal LaForgia, Kay Huebner, Kari Alitalo

Research output: Contribution to journalArticlepeer-review

Abstract

The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined.

Original languageEnglish
Pages (from-to)2009-2014
Number of pages6
JournalOncogene
Volume8
Issue number7
Publication statusPublished - Jul 1993

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain'. Together they form a unique fingerprint.

Cite this