TY - JOUR
T1 - The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization
AU - Gentile, V.
AU - Davies, P. J A
AU - Baldini, A.
PY - 1994
Y1 - 1994
N2 - A cDNA encoding for the human tissue transglutaminase gene has been used to identify the chromosomal localization of the corresponding structural gene. The precise chromosomal and subregional localizations have been established by using in situ fluorescence mapping with a recombinant λ-Zap phage containing the full cDNA coding sequence. The study showed that the human tissue transglutaminase gene is localized on chromosome 20 and, more precisely, within the band 20q12. To date, this is the third member of the transglutaminase gene family to be mapped. Human factor XIIIa (plasma transglutaminase), human keratinocyte transglutaminase (type I), and human tissue transglutaminase (type II) genes, although codifying for homologous enzymes, are localized on three different chromosomes.
AB - A cDNA encoding for the human tissue transglutaminase gene has been used to identify the chromosomal localization of the corresponding structural gene. The precise chromosomal and subregional localizations have been established by using in situ fluorescence mapping with a recombinant λ-Zap phage containing the full cDNA coding sequence. The study showed that the human tissue transglutaminase gene is localized on chromosome 20 and, more precisely, within the band 20q12. To date, this is the third member of the transglutaminase gene family to be mapped. Human factor XIIIa (plasma transglutaminase), human keratinocyte transglutaminase (type I), and human tissue transglutaminase (type II) genes, although codifying for homologous enzymes, are localized on three different chromosomes.
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U2 - 10.1006/geno.1994.1170
DO - 10.1006/geno.1994.1170
M3 - Article
C2 - 7912692
AN - SCOPUS:0028220758
VL - 20
SP - 295
EP - 297
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -