The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps

Sébastien Jaillon, Giuseppe Peri, Yves Delneste, Isabelle Frémaux, Andrea Doni, Federica Moalli, Cecilia Garlanda, Luigina Romani, Hugues Gascan, Silvia Bellocchio, Silvia Bozza, Marco A. Cassatella, Pascale Jeannin, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in response to Toll-like receptor agonists and represents a nonredundant component of humoral innate immunity against selected pathogens. We report that, unexpectedly, PTX3 is stored in specific granules and undergoes release in response to microbial recognition and infl ammatory signals. Released PTX3 can partially localize in neutrophil extracellular traps formed by extruded DNA. Eosinophils and basophils do not contain preformed PTX3. PTX3-deficient neutrophils have defective microbial recognition and phagocytosis, and PTX3 is nonredundant for neutrophil-mediated resistance against Aspergillus fumigatus. Thus, neutrophils serve as a reservoir, ready for rapid release, of the long PTX3, a key component of humoral innate immunity with opsonic activity. JEM

Original languageEnglish
Pages (from-to)793-804
Number of pages12
JournalJournal of Experimental Medicine
Volume204
Issue number4
DOIs
Publication statusPublished - Apr 16 2007

ASJC Scopus subject areas

  • Immunology

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    Jaillon, S., Peri, G., Delneste, Y., Frémaux, I., Doni, A., Moalli, F., Garlanda, C., Romani, L., Gascan, H., Bellocchio, S., Bozza, S., Cassatella, M. A., Jeannin, P., & Mantovani, A. (2007). The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. Journal of Experimental Medicine, 204(4), 793-804. https://doi.org/10.1084/jem.20061301