The hygiene hypothesis: an evolutionary perspective

Research output: Contribution to journalArticlepeer-review


The hygiene hypothesis relies on the assumption that humans have adapted to a pathogen-rich environment that no longer exists in industrialized societies. Recent advances in molecular immunology and population genetics allow deeper insight into the evolution and co-evolution of host-pathogen interactions and, therefore, into the foundations of the hygiene hypothesis.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalMicrobes and Infection
Issue number6
Publication statusPublished - Jun 2010


  • Host-pathogen interactions
  • Natural selection
  • Population genetics

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases
  • Medicine(all)


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