La "memoria metabólica" inducida por la hiperglucemia: El nuevo reto en la prevención de la enfermedad cardiovascular en la diabetes

Translated title of the contribution: The hyperglycemia-induced "metabolic memory": The new challenge for the prevention of CVD in diabetes

Research output: Contribution to journalArticlepeer-review

Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as "metabolic memory." Potential mechanisms for propagating this "memory" are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signaling. Furthermore, the emergence of this "metabolic memory" suggests the need of a very early aggressive treatment aiming to "normalize" the metabolic control and the addition of agents which reduce cellular reactive species and glycation in addition to normalizing glucose levels in diabetic patients in order to minimize long-term diabetic complications.

Translated title of the contributionThe hyperglycemia-induced "metabolic memory": The new challenge for the prevention of CVD in diabetes
Original languageSpanish
JournalRevista Espanola de Cardiologia Suplementos
Volume8
Issue numberC
DOIs
Publication statusPublished - May 2008

Keywords

  • Diabetic complications
  • Metabolic memory
  • Mitochondria
  • Non-enzymatic glycation
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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