The hypothalamic-neurohypophyseal system: Current and future treatment of vasopressin and oxytocyn related disorders

Rocco S. Calabrò, Domenico Italiano, Danilo Ferrara, Stefania Mondello, Valeria Conti-Nibali, Carlo Salviera, Placido Bramanti

Research output: Contribution to journalArticlepeer-review

Abstract

The hypothalamus and posterior pituitary form a complex neurohumoral system playing a key role in maintaining body fluid homeostasis and reproductive function. We review the pathophysiology mechanisms of posterior pituitary hormones and their implications, beyond water balance and delivery, in social functioning, pair bonding and affiliative behavior. Actual and future treatments for neurohypophysis related disorders are also discussed, particularly focusing on the development of new therapeutic compounds and patents.

Original languageEnglish
Pages (from-to)235-250
Number of pages16
JournalRecent Patents on Endocrine, Metabolic and Immune Drug Discovery
Volume6
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Hypothalamus
  • Neurohypophysis
  • Oxytocin
  • Pituitary
  • Treatment
  • Vasopressin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Drug Discovery
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry, medical

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