Abstract
Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.
| Original language | English |
|---|---|
| Article number | 0011 |
| Journal | Oncogenesis |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
Cite this
The hypoxic tumour microenvironment. / Petrova, Varvara; Annicchiarico-Petruzzelli, Margherita; Melino, Gerry; Amelio, Ivano.
In: Oncogenesis, Vol. 7, No. 1, 0011, 01.01.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The hypoxic tumour microenvironment
AU - Petrova, Varvara
AU - Annicchiarico-Petruzzelli, Margherita
AU - Melino, Gerry
AU - Amelio, Ivano
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.
AB - Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.
UR - http://www.scopus.com/inward/record.url?scp=85040964568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040964568&partnerID=8YFLogxK
U2 - 10.1038/s41389-017-0011-9
DO - 10.1038/s41389-017-0011-9
M3 - Review article
AN - SCOPUS:85040964568
VL - 7
JO - Oncogenesis
JF - Oncogenesis
SN - 2157-9024
IS - 1
M1 - 0011
ER -