TY - JOUR
T1 - The Ideal Thrombolytic Agent
T2 - GISSI‐2 and ISIS‐3
AU - MAGGIONI, ALDO PIETRO
AU - FRESCO, CLAUDIO
AU - FRANZOSI, MARIA GRAZIA
AU - TOGNONI, GIANNI
AU - GISSI‐2 INVESTIGATORS
PY - 1990
Y1 - 1990
N2 - Streptokinase (SK) and tissue plasminogen activator (alteplase [tPA]) are by far the most intensively studied thrombolytic agents, but only recently a direct head‐to‐head comparison (GISSI‐2 Trial, in which 12,490 patients have been randomized) has become available to the scientific community. This trial, with its international extension (the International tPA/SK Mortality Trial) recruited more than 20,000 patients, showed that the two drugs tested (SK and tPA) were substantially comparable as far as the clinical events were considered. ISIS‐3, the largest randomized clinical trial ever performed, compares SK, tPA, and APSAC in a factorial design. Its results will be available before spring, 1991. It is likely that these two studies, if the results will be consistent, will give a definitive answer about comparison among thrombolytic drugs. As a consequence of that achievement, the interest of the scientific community will possibly be directed towards the long‐term prevention of the infarct complications, namely ventricular remodeling and infarct expansion or life‐threatening arrhythmias.
AB - Streptokinase (SK) and tissue plasminogen activator (alteplase [tPA]) are by far the most intensively studied thrombolytic agents, but only recently a direct head‐to‐head comparison (GISSI‐2 Trial, in which 12,490 patients have been randomized) has become available to the scientific community. This trial, with its international extension (the International tPA/SK Mortality Trial) recruited more than 20,000 patients, showed that the two drugs tested (SK and tPA) were substantially comparable as far as the clinical events were considered. ISIS‐3, the largest randomized clinical trial ever performed, compares SK, tPA, and APSAC in a factorial design. Its results will be available before spring, 1991. It is likely that these two studies, if the results will be consistent, will give a definitive answer about comparison among thrombolytic drugs. As a consequence of that achievement, the interest of the scientific community will possibly be directed towards the long‐term prevention of the infarct complications, namely ventricular remodeling and infarct expansion or life‐threatening arrhythmias.
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U2 - 10.1111/j.1540-8183.1990.tb00976.x
DO - 10.1111/j.1540-8183.1990.tb00976.x
M3 - Article
VL - 3
SP - 157
EP - 168
JO - Journal of Interventional Cardiology
JF - Journal of Interventional Cardiology
SN - 0896-4327
IS - 3
ER -