Identificazione della malattia residua minima nel midollo e nel sangue periferico nel neuroblastoma. Implicazioni prognostiche e terapeutiche.

Translated title of the contribution: The identification of minimal residual disease in the bone marrow and peripheral blood in neuroblastoma. The prognostic and therapeutic implications

L. B. Faulkner, A. Tamburini, V. Tintori, A. Paoli, A. Tondo, G. Bernini, D. Medicina, M. Brisigotti, M. V. Corrias, P. Scaruffi, C. Rosanda, M. S. Lo Piccolo, E. Viscardi, C. Milanaccio, A. Garaventa, B. De Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

A highly sensitive and specific methodology to detect neuroblastoma cells in the bone marrow and peripheral blood of children with neuroblastoma is of critical importance for proper staging and treatment of these patients. In addition, patients with bone marrow infiltration at diagnosis need to undergo regular investigation to measure the effectiveness of chemotherapy (so called "in vivo" purging). Finally, the evaluation of autologous stem cells taken from bone marrow or peripheral blood is necessary to rule out or minimise the possibility of reinfusing tumor cells to the patient following myeloablative therapy. The authors provide a "state of the art" data on this complicated issue and give their preliminary results of their own experience, mainly concerning the immunocytological methods.

Translated title of the contributionThe identification of minimal residual disease in the bone marrow and peripheral blood in neuroblastoma. The prognostic and therapeutic implications
Original languageItalian
Pages (from-to)175-178
Number of pages4
JournalPediatria Medica e Chirurgica
Volume20
Issue number3
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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