The idiopathic forms of premature menopause and early menopause show the same genetic pattern

M. G. Tibiletti, G. Testa, W. Vegetti, F. Alagna, M. Taborelli, L. Dalprà, P. F. Bolis, P. G. Crosignani

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic factors may influence the timing of menopause. Premature ovarian failure (POF) has recently been identified as a genetic entity, but no genetic data are available on early menopause (EM). We investigated 36 patients with EM (age of menopause between 40 and 45 years of age) using cytogenetic and pedigree analysis. In 30 patients of this study the EM was idiopathic and 15 subjects (50%) had a familial condition of EM or POF. Pedigree analysis revealed a dominant pattern of inheritance of EM through maternal or paternal relatives. Our data reveal that POF and fill patients show the same genetic features and we postulate that these conditions may be a variable expression of the same genetic disease.

Original languageEnglish
Pages (from-to)2731-2734
Number of pages4
JournalHuman Reproduction
Volume14
Issue number11
DOIs
Publication statusPublished - 1999

Keywords

  • Early menopause
  • Familiarity
  • Genetics

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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