Abstract
Purpose of Review: To define the role of IgE-microarray testing in atopic dermatitis where the multifunctional environmental factors implicated in the pathogenesis of the disease deserve a complex and exhaustive approach for the finest definition of relevant allergenic triggers, if any. Recent Findings: Allergenic factors involved in atopic dermatitis have been reported in inducing atopic dermatitis. Environmental triggers, such as aeroallergens, food allergens, bacterial, and fungal antigen, and the presence of IgE to self-antigens have been described as well. The usefulness of the microarray testing has been preliminary described. Summary: As far as the number of potential triggers or worsening factors in atopic dermatitis is quite broad, we foresee a crucial role for the IgE microarray testing. The microarray testing is helpful in defining all additional reactivity the atopic dermatitis patient could have acquired in her/his allergic life, mostly related to inhalant allergens. Nevertheless, interpretation needs skills and thus this new technology should rather be reserved for the allergologist as it may lead to false conclusions if broadly used in general medicine. IgE microarray testing gives trustable results to define the nonallergic atopic dermatitis form because of the broad and comprehensive negative IgE testing.
| Original language | English |
|---|---|
| Pages (from-to) | 438-444 |
| Number of pages | 7 |
| Journal | Current Opinion in Allergy and Clinical Immunology |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- allergenic molecules
- atopic dermatitis
- diagnosis
- IgE
- microarray
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
The IgE-microarray testing in atopic dermatitis : A suitable modern tool for the immunological and clinical phenotyping of the disease. / Mari, Adriano; Scala, Enrico; Alessandri, Claudia.
In: Current Opinion in Allergy and Clinical Immunology, Vol. 11, No. 5, 10.2011, p. 438-444.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The IgE-microarray testing in atopic dermatitis
T2 - A suitable modern tool for the immunological and clinical phenotyping of the disease
AU - Mari, Adriano
AU - Scala, Enrico
AU - Alessandri, Claudia
PY - 2011/10
Y1 - 2011/10
N2 - Purpose of Review: To define the role of IgE-microarray testing in atopic dermatitis where the multifunctional environmental factors implicated in the pathogenesis of the disease deserve a complex and exhaustive approach for the finest definition of relevant allergenic triggers, if any. Recent Findings: Allergenic factors involved in atopic dermatitis have been reported in inducing atopic dermatitis. Environmental triggers, such as aeroallergens, food allergens, bacterial, and fungal antigen, and the presence of IgE to self-antigens have been described as well. The usefulness of the microarray testing has been preliminary described. Summary: As far as the number of potential triggers or worsening factors in atopic dermatitis is quite broad, we foresee a crucial role for the IgE microarray testing. The microarray testing is helpful in defining all additional reactivity the atopic dermatitis patient could have acquired in her/his allergic life, mostly related to inhalant allergens. Nevertheless, interpretation needs skills and thus this new technology should rather be reserved for the allergologist as it may lead to false conclusions if broadly used in general medicine. IgE microarray testing gives trustable results to define the nonallergic atopic dermatitis form because of the broad and comprehensive negative IgE testing.
AB - Purpose of Review: To define the role of IgE-microarray testing in atopic dermatitis where the multifunctional environmental factors implicated in the pathogenesis of the disease deserve a complex and exhaustive approach for the finest definition of relevant allergenic triggers, if any. Recent Findings: Allergenic factors involved in atopic dermatitis have been reported in inducing atopic dermatitis. Environmental triggers, such as aeroallergens, food allergens, bacterial, and fungal antigen, and the presence of IgE to self-antigens have been described as well. The usefulness of the microarray testing has been preliminary described. Summary: As far as the number of potential triggers or worsening factors in atopic dermatitis is quite broad, we foresee a crucial role for the IgE microarray testing. The microarray testing is helpful in defining all additional reactivity the atopic dermatitis patient could have acquired in her/his allergic life, mostly related to inhalant allergens. Nevertheless, interpretation needs skills and thus this new technology should rather be reserved for the allergologist as it may lead to false conclusions if broadly used in general medicine. IgE microarray testing gives trustable results to define the nonallergic atopic dermatitis form because of the broad and comprehensive negative IgE testing.
KW - allergenic molecules
KW - atopic dermatitis
KW - diagnosis
KW - IgE
KW - microarray
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UR - http://www.scopus.com/inward/citedby.url?scp=80052439188&partnerID=8YFLogxK
U2 - 10.1097/ACI.0b013e32834a41dd
DO - 10.1097/ACI.0b013e32834a41dd
M3 - Article
C2 - 21772137
AN - SCOPUS:80052439188
VL - 11
SP - 438
EP - 444
JO - Current Opinion in Allergy and Clinical Immunology
JF - Current Opinion in Allergy and Clinical Immunology
SN - 1528-4050
IS - 5
ER -