Abstract
The interleukin (IL)-17A/IL-17 receptor A (IL-17RA) axis is emerging as a key player in host defence. Several studies have demonstrated that IL-17A-mediated responses play a critical role in both acute and chronic inflammation induced by infectious agents, environmental stimuli and genetic diseases in the airways. In this regard, it is becoming evident that IL-17A/IL-17RA signalling may have a protective and beneficial impact on health, but that it can also result in detrimental outcomes. On one hand, the IL-17A/IL-17RA axis can contribute to the elimination of noxious stimuli and to the resolution of acute inflammatory processes; on the other hand, it can exacerbate immunopathological responses, contributing to the development and progression of chronic respiratory illnesses. In addition, cellular and molecular signatures underlying IL-17A/IL-17RA signalling have been increasingly identified, although further studies are needed to clarify such complex responses. Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology.
| Original language | English |
|---|---|
| Pages (from-to) | 19-27 |
| Number of pages | 9 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 30 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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Keywords
- Host defence
- Immunopathology
- Interleukin (IL)-17 receptor A
- Interleukin (IL)-17A
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Immunology
- Biochemistry, Genetics and Molecular Biology(all)