The IL-2 receptor complex: Expression and function on normal and leukemic B cells

D. De Totero, P. F. Di Celle, A. Cignetti, R. Foa

Research output: Contribution to journalArticlepeer-review

Abstract

The interleukin 2 receptor (IL-2R) is composed of at least three different chains that may be variably expressed on normal and neoplastic lymphocytes. While considerable knowledge has been gained on the expression of the IL-2R α chain on human leukemic cells of different origin, less is known of the β and γ chains. In view of the highly pleiotropic functions exerted by IL-2, the IL-2-IL-2R interactions may play an important role in various leukemias. In this review we focus on the expression and function of the IL-2R complex on human normal and leukemic B cells. Possible implications in the expansion of the neoplastic clone and in the clinical course of the disease are discussed.

Original languageEnglish
Pages (from-to)1425-1431
Number of pages7
JournalLeukemia
Volume9
Issue number9
Publication statusPublished - 1995

Keywords

  • ALL
  • B-CLL
  • HCL
  • IL-2
  • IL-2 receptor
  • Leukemic B cells
  • Normal B cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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