The immunogenicity of experimental tumors is strongly biased by the expression of dominant viral cytotoxic T-lymphocyte epitopes

Giandomenica Iezzi, Loredana Rivolta, Anna Ronchetti, Alfonso Martin-Fontecha, Antonio Rosato, Maria Pia Protti, Maria Grazia Sabbadini, Matteo Bellone

Research output: Contribution to journalArticle

Abstract

The immunogenic Friend-Moloney-Rauscher (FMR) virus-induced tumors have been used extensively to clarify the cellular and molecular mechanisms responsible for tumor rejection and to develop immunotherapeutic strategies. We characterize here the trimolecular complex MHC class 1-antigenic determinant-T cell receptor involved in the induction of a protective CTL response against the RMA thymoma. This complex is mainly composed by the D(b) molecule interacting with a Rauscher virus antigen (Ag) determinant and the Vβ5+ T cell receptor. We also show that the chemically induced EL-4 thymoma acquires the susceptibility to recognition by anti-RMA CTLs and the ability to elicit a protective anti-RMA CTL response only upon infection by a virus of the FMR family and that RMA and FMR virus infected EL-4 cells share tumor- associated Ag. The data strongly support the hypothesis that the high immunogenicity of virus-induced or infected tumors is determined by the expression of immunodominant virus-encoded Ag. The demonstration of a different outcome in the immune responses elicited in the presence or in the absence of viral Ag further open the contention of the molecular requirements for immunogenicity and should stimulate a more careful revision of unexpected cross-reactivity among tumors.

Original languageEnglish
Pages (from-to)2564-2568
Number of pages5
JournalCancer Research
Volume57
Issue number13
Publication statusPublished - Jul 1 1997

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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