The immunomodulatory role of vitamin D in respiratory diseases

Giulio Pulvirenti, Giuseppe Fabio Parisi, Sara Manti, Amelia Licari, Michele Miraglia Del Giudice, Carmelo Salpietro, Gian Luigi Marseglia, Salvatore Leonardi

Research output: Contribution to journalReview articlepeer-review


The growing interest in the new role of vitamin D, particularly as an immunomodulatory factor, has spurred basic research and the development of clinical trials to better understand the influence of supplementation on various diseases. Vitamin D is an important nutrient factor in human health due to its role in calcium metabolism regulation, cellular growth, differentiation and its fundamental discovered activity in immune functions. It has influenced different diseases, particularly inflammatory and autoimmune diseases, through immune response regulation, modulating innate and adaptive immunity. The aim of this review was to explore the role of vitamin D in the main respiratory diseases in children such as asthma, chronic rhinosinusitis, cystic fibrosis and recurrent respiratory infections.

Original languageEnglish
Pages (from-to)238-245
Number of pages8
JournalCurrent Respiratory Medicine Reviews
Issue number3
Publication statusPublished - 2019


  • Asthma
  • Cystic fibrosis
  • Immunomodulatory
  • Recurrent respiratory infections
  • Respiratory disease
  • Vitamin D

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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