The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: Two triggers for one disease?

Research output: Contribution to journalArticlepeer-review

Abstract

Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage.

Original languageEnglish
Pages (from-to)359-369
Number of pages11
JournalSeminars in Immunopathology
Volume31
Issue number3
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Cytokine
  • Inflammation
  • Insulin resistance
  • Kupffer cell
  • Steatosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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