TY - JOUR
T1 - The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis
T2 - Two triggers for one disease?
AU - Valenti, Luca
AU - Ludovica Fracanzani, Anna
AU - Fargion, Silvia
PY - 2009/9
Y1 - 2009/9
N2 - Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage.
AB - Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage.
KW - Cytokine
KW - Inflammation
KW - Insulin resistance
KW - Kupffer cell
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=70349570846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349570846&partnerID=8YFLogxK
U2 - 10.1007/s00281-009-0152-9
DO - 10.1007/s00281-009-0152-9
M3 - Article
C2 - 19440711
AN - SCOPUS:70349570846
VL - 31
SP - 359
EP - 369
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
SN - 1863-2297
IS - 3
ER -