The impact of arterial cannulation strategy on operative outcomes in aortic surgery: Evidence from a comprehensive meta-analysis of comparative studies on 4476 patients

Umberto Benedetto, Shahzad G. Raja, Mohamed Amrani, John R. Pepper, Mohamed Zeinah, Euclide Tonelli, Giuseppe Biondi-Zoccai, Giacomo Frati

Research output: Contribution to journalArticle


Objectives There is a growing perception that peripheral cannulation through the femoral artery, by reversing the flow in the thoracoabdominal aorta, may increase the risk of retrograde brain embolization in aortic surgery. Central cannulation sites, including the right axillary artery, have been reported to improve operative outcomes by allowing antegrade blood flow. However, peripheral cannulation still remains largely used because a consensus for the routine use of central cannulation approaches has not been reached.

Results A total of 4476 patients were included in the final analysis. Central cannulation was used in 2797 patients, and peripheral cannulation was used in 1679 patients. Central cannulation showed a protective effect on in-hospital mortality (risk ratio, 0.59; 95% confidence interval, 0.48-0.7; P 2 = 0%).

Conclusions Central cannulation was superior to peripheral cannulation in reducing in-hospital mortality and the incidence of permanent neurologic deficit. This superiority was particularly evident when the axillary artery was used for central cannulation.

Original languageEnglish
Pages (from-to)2936-2943
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number6
Publication statusPublished - Dec 1 2014


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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