The impact of body mass index and type 2 diabetes on breast cancer: Current therapeutic measures of prevention

F. Resta, V. Triggiani, C. Sabbà, B. Licchelli, S. Ghiyasaldin, A. Liso, F. Schittulli, M. Quaranta, A. Paradiso, E. Tafaro, E. Guastanacchia

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological data have suggested a possible relationship between obesity, diabetes mellitus and cancer risk, particularly breast cancer. We set out to investigate the effect of body mass index and diabetes mellitus on the presence of breast cancer in the Apulian population. We selected 1,663 women affected with primary breast cancer and 4,702 control patients. All patients with breast cancer underwent surgical excision of the tumor and their tumors were histologically confirmed. The prevalence of type 2 diabetes (8%) in the women affected by breast cancer was significantly higher than in the control group (5%) (p25, both in premenopause and in postmenopause. With respect to BMI, the non-diabetic patients with breast cancer in postmenopause showed the same pattern as the diabetic ones. Instead, among the women in premenopause a higher percentage (55%) of patients with a BMI

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalCurrent Drug Targets: Immune, Endocrine and Metabolic Disorders
Volume4
Issue number4
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Body mass index
  • Breast cancer
  • Diabetes
  • Menopause

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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