The impact of center experience on results of reduced intensity: Allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

S. Giebel, M. Labopin, M. Mohty, G. J. Mufti, D. Niederwieser, J. J. Cornelissen, J. J W M Janssen, N. Milpied, L. Vindelov, E. Petersen, R. Arnold, A. Bacigalupo, D. Blaise, C. Craddock, A. Nagler, F. Frassoni, M. Sadus-Wojciechowska, V. Rocha

Research output: Contribution to journalArticle

Abstract

Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or unrelated donors for adult patients with AML in first CR were analyzed according to the level of center activity. Transplants were performed in 203 European centers between 2001 and 2007. The 2-year probability of leukemia-free survival (LFS) after RIC-HSCT performed in centers with the lowest activity (≤15 procedures/7 years) was 43±3% compared with 55±2% in the remainder (P

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalBone Marrow Transplantation
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • acute myeloid leukemia
  • center experience
  • hematopoietic SCT
  • reduced-intensity conditioning

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Giebel, S., Labopin, M., Mohty, M., Mufti, G. J., Niederwieser, D., Cornelissen, J. J., Janssen, J. J. W. M., Milpied, N., Vindelov, L., Petersen, E., Arnold, R., Bacigalupo, A., Blaise, D., Craddock, C., Nagler, A., Frassoni, F., Sadus-Wojciechowska, M., & Rocha, V. (2013). The impact of center experience on results of reduced intensity: Allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation, 48(2), 238-242. https://doi.org/10.1038/bmt.2012.131