The impact of concomitant diffuse idiopathic skeletal hyperostosis on the achievement of minimal disease activity in subjects with psoriatic arthritis

Nicola Pappone, Matteo Nicola Dario Di Minno, Salvatore Iervolino, Roberta Lupoli, Reuven Mader, Carmela Zincarelli, Rosario Peluso

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheses. Psoriatic arthritis (PsA) is a seronegative spondyloarthritis associated with psoriasis. Given the possible overlap of the two diseases, we assessed whether DISH presence may affect PsA clinical outcomes. Also, predictors of DISH presence in the cohort were investigated. Consecutive PsA patients from two Italian Rheumatology Research Units were enrolled. Subjects were splitted into two groups, according to the current treatment (TNF-α blockers or traditional DMARDs). All patients underwent a rheumatologic examination, blood sample collections and spine radiographs. Information about traditional vascular risk factors was recorded. In each patient, the presence of minimal disease activity was evaluated and the presence of DISH was established according to the Resnick and Niwayama criteria. Among the 80 enrolled subjects (57.5 % men, mean age 56.5 ± 11.1 years), the overall prevalence of DISH was 30.0 %. Patients with DISH were older, with higher BMI and waist circumference. DISH subjects showed worsen BASMI, HAQ and ESR. In a multivariate regression model, BASMI was a significant predictor of DISH presence (OR 3.027, 95 % CI 1.449–6.325, p = 0.003). The prevalence of MDA was lower in DISH patients than in no-DISH (16.7 vs 41.1 %, p = 0.041), and the presence of DISH was a predictor of not achieving MDA (OR 3.485, 95 % CI 1.051–11.550, p = 0.041). PsA subjects with DISH showed worsen indices of spine mobility and articular function and lower prevalence of minimal disease activity than no-DISH patients.

Original languageEnglish
Pages (from-to)2041-2046
Number of pages6
JournalRheumatology International
Volume35
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Diffuse Idiopathic Skeletal Hyperostosis
Psoriatic Arthritis
ametantrone
Spine
Antirheumatic Agents
Rheumatology
Waist Circumference
Psoriasis

Keywords

  • Diffuse idiopathic skeletal hyperostosis
  • Minimal disease activity
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

The impact of concomitant diffuse idiopathic skeletal hyperostosis on the achievement of minimal disease activity in subjects with psoriatic arthritis. / Pappone, Nicola; Di Minno, Matteo Nicola Dario; Iervolino, Salvatore; Lupoli, Roberta; Mader, Reuven; Zincarelli, Carmela; Peluso, Rosario.

In: Rheumatology International, Vol. 35, No. 12, 01.12.2015, p. 2041-2046.

Research output: Contribution to journalArticle

Pappone, Nicola ; Di Minno, Matteo Nicola Dario ; Iervolino, Salvatore ; Lupoli, Roberta ; Mader, Reuven ; Zincarelli, Carmela ; Peluso, Rosario. / The impact of concomitant diffuse idiopathic skeletal hyperostosis on the achievement of minimal disease activity in subjects with psoriatic arthritis. In: Rheumatology International. 2015 ; Vol. 35, No. 12. pp. 2041-2046.
@article{e24e535714f74dfeb4bb93c087d8a8ad,
title = "The impact of concomitant diffuse idiopathic skeletal hyperostosis on the achievement of minimal disease activity in subjects with psoriatic arthritis",
abstract = "Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheses. Psoriatic arthritis (PsA) is a seronegative spondyloarthritis associated with psoriasis. Given the possible overlap of the two diseases, we assessed whether DISH presence may affect PsA clinical outcomes. Also, predictors of DISH presence in the cohort were investigated. Consecutive PsA patients from two Italian Rheumatology Research Units were enrolled. Subjects were splitted into two groups, according to the current treatment (TNF-α blockers or traditional DMARDs). All patients underwent a rheumatologic examination, blood sample collections and spine radiographs. Information about traditional vascular risk factors was recorded. In each patient, the presence of minimal disease activity was evaluated and the presence of DISH was established according to the Resnick and Niwayama criteria. Among the 80 enrolled subjects (57.5 {\%} men, mean age 56.5 ± 11.1 years), the overall prevalence of DISH was 30.0 {\%}. Patients with DISH were older, with higher BMI and waist circumference. DISH subjects showed worsen BASMI, HAQ and ESR. In a multivariate regression model, BASMI was a significant predictor of DISH presence (OR 3.027, 95 {\%} CI 1.449–6.325, p = 0.003). The prevalence of MDA was lower in DISH patients than in no-DISH (16.7 vs 41.1 {\%}, p = 0.041), and the presence of DISH was a predictor of not achieving MDA (OR 3.485, 95 {\%} CI 1.051–11.550, p = 0.041). PsA subjects with DISH showed worsen indices of spine mobility and articular function and lower prevalence of minimal disease activity than no-DISH patients.",
keywords = "Diffuse idiopathic skeletal hyperostosis, Minimal disease activity, Psoriatic arthritis",
author = "Nicola Pappone and {Di Minno}, {Matteo Nicola Dario} and Salvatore Iervolino and Roberta Lupoli and Reuven Mader and Carmela Zincarelli and Rosario Peluso",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s00296-015-3303-4",
language = "English",
volume = "35",
pages = "2041--2046",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - The impact of concomitant diffuse idiopathic skeletal hyperostosis on the achievement of minimal disease activity in subjects with psoriatic arthritis

AU - Pappone, Nicola

AU - Di Minno, Matteo Nicola Dario

AU - Iervolino, Salvatore

AU - Lupoli, Roberta

AU - Mader, Reuven

AU - Zincarelli, Carmela

AU - Peluso, Rosario

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheses. Psoriatic arthritis (PsA) is a seronegative spondyloarthritis associated with psoriasis. Given the possible overlap of the two diseases, we assessed whether DISH presence may affect PsA clinical outcomes. Also, predictors of DISH presence in the cohort were investigated. Consecutive PsA patients from two Italian Rheumatology Research Units were enrolled. Subjects were splitted into two groups, according to the current treatment (TNF-α blockers or traditional DMARDs). All patients underwent a rheumatologic examination, blood sample collections and spine radiographs. Information about traditional vascular risk factors was recorded. In each patient, the presence of minimal disease activity was evaluated and the presence of DISH was established according to the Resnick and Niwayama criteria. Among the 80 enrolled subjects (57.5 % men, mean age 56.5 ± 11.1 years), the overall prevalence of DISH was 30.0 %. Patients with DISH were older, with higher BMI and waist circumference. DISH subjects showed worsen BASMI, HAQ and ESR. In a multivariate regression model, BASMI was a significant predictor of DISH presence (OR 3.027, 95 % CI 1.449–6.325, p = 0.003). The prevalence of MDA was lower in DISH patients than in no-DISH (16.7 vs 41.1 %, p = 0.041), and the presence of DISH was a predictor of not achieving MDA (OR 3.485, 95 % CI 1.051–11.550, p = 0.041). PsA subjects with DISH showed worsen indices of spine mobility and articular function and lower prevalence of minimal disease activity than no-DISH patients.

AB - Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheses. Psoriatic arthritis (PsA) is a seronegative spondyloarthritis associated with psoriasis. Given the possible overlap of the two diseases, we assessed whether DISH presence may affect PsA clinical outcomes. Also, predictors of DISH presence in the cohort were investigated. Consecutive PsA patients from two Italian Rheumatology Research Units were enrolled. Subjects were splitted into two groups, according to the current treatment (TNF-α blockers or traditional DMARDs). All patients underwent a rheumatologic examination, blood sample collections and spine radiographs. Information about traditional vascular risk factors was recorded. In each patient, the presence of minimal disease activity was evaluated and the presence of DISH was established according to the Resnick and Niwayama criteria. Among the 80 enrolled subjects (57.5 % men, mean age 56.5 ± 11.1 years), the overall prevalence of DISH was 30.0 %. Patients with DISH were older, with higher BMI and waist circumference. DISH subjects showed worsen BASMI, HAQ and ESR. In a multivariate regression model, BASMI was a significant predictor of DISH presence (OR 3.027, 95 % CI 1.449–6.325, p = 0.003). The prevalence of MDA was lower in DISH patients than in no-DISH (16.7 vs 41.1 %, p = 0.041), and the presence of DISH was a predictor of not achieving MDA (OR 3.485, 95 % CI 1.051–11.550, p = 0.041). PsA subjects with DISH showed worsen indices of spine mobility and articular function and lower prevalence of minimal disease activity than no-DISH patients.

KW - Diffuse idiopathic skeletal hyperostosis

KW - Minimal disease activity

KW - Psoriatic arthritis

UR - http://www.scopus.com/inward/record.url?scp=84947616312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947616312&partnerID=8YFLogxK

U2 - 10.1007/s00296-015-3303-4

DO - 10.1007/s00296-015-3303-4

M3 - Article

VL - 35

SP - 2041

EP - 2046

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 12

ER -