TY - JOUR
T1 - The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers
T2 - A Nation-Wide Survey
AU - Wosa Group
AU - Rainero, Innocenzo
AU - Bruni, Amalia C.
AU - Marra, Camillo
AU - Cagnin, Annachiara
AU - Bonanni, Laura
AU - Cupidi, Chiara
AU - Laganà, Valentina
AU - Rubino, Elisa
AU - Vacca, Alessandro
AU - Lorenzo, Raffaele Di
AU - Provero, Paolo
AU - Isella, Valeria
AU - Vanacore, Nicola
AU - Agosta, Federica
AU - Appollonio, Ildebrando
AU - Caffarra, Paolo
AU - Bussè, Cinzia
AU - Sambati, Renato
AU - Quaranta, Davide
AU - Guglielmi, Valeria
AU - Logroscino, Giancarlo
AU - Filippi, Massimo
AU - Tedeschi, Gioacchino
AU - Ferrarese, Carlo
AU - Gallo, Erica
AU - Grassini, Alberto
AU - Marcinnò, Andrea
AU - Roveta, Fausto
AU - De Martino, Paola
AU - Frangipane, Francesca
AU - Puccio, Gianfranco
AU - Sacco, Simona
AU - Tiraboschi, Pietro
AU - Caroppo, Paola
AU - Redaelli, Veronica
AU - Di Fede, Giuseppe
AU - Sambati, Luisa
AU - Magarelli, Silvia
AU - Spalletta, Gianfranco
AU - Banaj, Nerisa
AU - Caruso, Giulia
AU - Estela Porcari, Desirée
AU - Brambilla, Michela
AU - Magnani, Giuseppe
AU - Caso, Francesca
AU - Spinelli, Edoardo G.
AU - Sinforiani, Elena
AU - Costa, Alfredo
AU - Giuli, Cinzia
AU - Castellano, Annaelisa
N1 - Funding Information:
This study was supported by Ministero dell’Istruzione, dell’Universitá e della Ricerca and MIUR project “Dipartimenti di Eccellenza 2018–2022” to Department of Neuroscience “Rita Levi Montalcini”.
Publisher Copyright:
© Copyright © 2021 Rainero, Bruni, Marra, Cagnin, Bonanni, Cupidi, Laganà, Rubino, Vacca, Di Lorenzo, Provero, Isella, Vanacore, Agosta, Appollonio, Caffarra, Bussè, Sambati, Quaranta, Guglielmi, Logroscino, Filippi, Tedeschi, Ferrarese and the SINdem COVID-19 Study Group.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/1/18
Y1 - 2021/1/18
N2 - Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.
AB - Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.
KW - Alzheimer’s disease
KW - BPSD
KW - caregiver burden
KW - COVID-19
KW - dementia
KW - quarantine
UR - http://www.scopus.com/inward/record.url?scp=85100536445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100536445&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2020.625781
DO - 10.3389/fnagi.2020.625781
M3 - Article
AN - SCOPUS:85100536445
VL - 12
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
SN - 1663-4365
M1 - 625781
ER -