The impact of diabetes and other metabolic disorders on prostate cancer prognosis

Jerry Polesel, Luigino Dal Maso, Andrea Gini, Carmen Stocco, Silvia Birri, Martina Taborelli, Diego Serraino, Antonella Zucchetto

Research output: Contribution to journalArticlepeer-review

Abstract

Aims To investigate the impact of diabetes mellitus (DM) and other metabolic disorders on the survival of men with prostate cancer (PCa). Methods We conducted a retrospective cohort-study based on 715 men with PCa, originally enrolled in an Italian case-control study between 1995 and 2002. Anthropometric measures, self-reported medical conditions, and Gleason score were assessed at enrollment. Adjusted hazard ratios (HRs) of death, with 95% confidence intervals (95% CIs), were estimated using Fine and Gray's regression model. Results After a median follow-up of 11.6 years, 244 (34.1%) deaths occurred, 77 (31.6%) due to PCa. Excess mortality from all causes was reported in PCa patients with DM (HR = 1.56, 95% CI: 1.03-2.36), which increased to 1.76 (95% CI: 0.99-3.13) when at least two out of three metabolic disorders (i.e., waist circumference ≥ 102 cm, drug-treated hypertension, and hypercholesterolemia) were additionally present. The impact of metabolic disorders was stronger on non-PCa-specific mortality with HRs equal to 2.21 (95% CI: 1.38-3.54) for DM, 1.45 (95% CI: 0.97-2.19) for waist circumference ≥ 102 cm, and 1.63 (95% CI: 1.19-2.22) for drug-treated hypertension. Conclusions DM and other metabolic disorders unfavorably affected the survival of PCa patients, mainly impacting on the risk of death from causes other than PCa.

Original languageEnglish
Pages (from-to)591-596
Number of pages6
JournalJournal of Diabetes and its Complications
Volume30
Issue number4
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Diabetes mellitus
  • Metabolic disorders
  • Obesity
  • Prostate cancer
  • Survival

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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