The impact of donor gender on outcome of allogeneic hematopoietic stem cell transplantation for multiple myeloma: Reduced relapse risk in female to male transplants

Gosta Gahrton, S. Iacobelli, J. Apperley, G. Bandini, B. Björkstrand, J. Bladé, J. M. Boiron, M. Cavo, J. Cornelissen, P. Corradini, N. Kröger, P. Ljungman, M. Michallet, N. H. Russell, D. Samson, A. Schattenberg, B. Sirohi, L. F. Verdonck, L. Volin, A. ZanderD. Niederwieser

Research output: Contribution to journalArticle

Abstract

The impact of the donor gender on outcome in HLA-identical sibling donor hematopoietic stem cell transplantation for multiple myeloma was studied in a retrospective registry study of 1312 patients (476 male to male (M → M); 334 female to male (F → M); 258 male to female (M → F); 244 female to female (F → F) reported to the European Group for Blood and Marrow Transplantation (EBMT). The best overall survival (OS) from the time of transplantation was found in F → F (median 41 months) with no significant difference between other groups (median 25 months in M → M, 18 months in F → M, 19 months in M → F) despite a significantly higher nonrelapse mortality in F → M. This was due to a significantly lower relapse rate (REL) in F → M compared to all other groups. Before 1994, OS was poorer in F → M than in M → M, which improved to similarity from 1994 onwards (median 29 months in M → M and 25 months in F → M). The reduced REL contributed to this improvement in F → M indicting a gender-specific graft vs myeloma effect. Therefore, a female donor is as good as a male one for male patients, while for female patients gender disparity is a negative factor for outcome.

Original languageEnglish
Pages (from-to)609-617
Number of pages9
JournalBone Marrow Transplantation
Volume35
Issue number6
DOIs
Publication statusPublished - Mar 2005

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Keywords

  • Allogeneic stem cell transplantation
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Gahrton, G., Iacobelli, S., Apperley, J., Bandini, G., Björkstrand, B., Bladé, J., Boiron, J. M., Cavo, M., Cornelissen, J., Corradini, P., Kröger, N., Ljungman, P., Michallet, M., Russell, N. H., Samson, D., Schattenberg, A., Sirohi, B., Verdonck, L. F., Volin, L., ... Niederwieser, D. (2005). The impact of donor gender on outcome of allogeneic hematopoietic stem cell transplantation for multiple myeloma: Reduced relapse risk in female to male transplants. Bone Marrow Transplantation, 35(6), 609-617. https://doi.org/10.1038/sj.bmt.1704861