The impact of drugs for multiple sclerosis on sleep

Giuseppe Lanza, Raffaele Ferri, Rita Bella

Research output: Contribution to journalArticle

Abstract

Although there is a growing literature on the presence of sleep disorders in multiple sclerosis (MS), few studies have specifically addressed the impact of drugs on sleep of these patients. Moreover, even when sleep is considered, quantitative assessment by standardized questionnaires or polysomnography is lacking. The studies that have been done highlight that interferon-beta and some symptomatic medications may affect sleep, thus contributing to fatigue, depression, and poor quality of life; conversely, natalizumab and cannabinoids may improve sleep. Common limitations of the literature reviewed here are small sample size, selection bias, and often a lack of objective outcome measures. Clinicians need to remember to ask about sleep in all MS patients and intervene when appropriate. A systematic approach that takes sleep into account is recommended to enhance recognition and appropriate management of sleep disruption, including disorders related to medication. Consideration of the impact on sleep should also be part of the design of trials of new therapies.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalMultiple Sclerosis
Volume23
Issue number1
DOIs
Publication statusE-pub ahead of print - Aug 8 2016

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Multiple Sclerosis
Sleep
Pharmaceutical Preparations
Cannabinoids
Selection Bias
Polysomnography
Interferon-beta
Sample Size
Fatigue
Quality of Life
Outcome Assessment (Health Care)
Depression

Keywords

  • Journal Article

Cite this

The impact of drugs for multiple sclerosis on sleep. / Lanza, Giuseppe; Ferri, Raffaele; Bella, Rita.

In: Multiple Sclerosis, Vol. 23, No. 1, 08.08.2016, p. 5-13.

Research output: Contribution to journalArticle

Lanza, Giuseppe ; Ferri, Raffaele ; Bella, Rita. / The impact of drugs for multiple sclerosis on sleep. In: Multiple Sclerosis. 2016 ; Vol. 23, No. 1. pp. 5-13.
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