The impact of first-trimester serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A on the diagnosis of fetal growth restriction and small for gestational age infant

Laura Montanari, Alessandro Alfei, Giulia Albonico, Remigio Moratti, Alessia Arossa, Fausta Beneventi, Arsenio Spinillo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To evaluate the risk of fetal growth restriction (FGR) associated with first-trimester maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG). Methods: A longitudinal study of 2,178 women who underwent first-trimester evaluation of serum PAPP-A and free β-hCG. FGR was defined as a decrement of the fetal abdominal circumference to below the 10th percentile of our standard growth curve in the presence of Doppler signs of impaired placental perfusion. Logistic regression was used to compute multivariable odds ratios and the estimated prevalences of outcomes associated with first-trimester serum marker concentrations. Results: The prevalences of small for gestational age (SGA,

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalFetal Diagnosis and Therapy
Volume25
Issue number1
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Pregnancy-Associated Plasma Protein-A
Small for Gestational Age Infant
Chorionic Gonadotropin
First Pregnancy Trimester
Fetal Development
Serum
Gestational Age
Longitudinal Studies
Perfusion
Biomarkers
Logistic Models
Odds Ratio
Mothers
Growth

Keywords

  • Fetal growth restriction
  • Preeclampsia
  • Pregnancy-associated plasma protein A

ASJC Scopus subject areas

  • Embryology
  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

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AU - Alfei, Alessandro

AU - Albonico, Giulia

AU - Moratti, Remigio

AU - Arossa, Alessia

AU - Beneventi, Fausta

AU - Spinillo, Arsenio

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