The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients

Carla Comacchio; Louise M Howard; Chiara Bonetto; Riccardo Lo Parrino; Karin Furlato; Enrico Semrov; Antonio Preti; Luca Mesiano; Giovanni Neri; Giovanni De Girolamo; Katia de Santi; Elisabetta Miglietta; Sarah Tosato; Doriana Cristofalo; Antonio Lasalvia; Mirella Ruggeri; GET UP Group

doi:10.1016/j.schres.2018.12.046

The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients

Carla Comacchio, Louise M Howard, Chiara Bonetto, Riccardo Lo Parrino, Karin Furlato, Enrico Semrov, Antonio Preti, Luca Mesiano, Giovanni Neri, Giovanni De Girolamo, Katia de Santi, Elisabetta Miglietta, Sarah Tosato, Doriana Cristofalo, Antonio Lasalvia, Mirella Ruggeri, GET UP Group

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Gender is associated with several features of psychotic disorders, including age of illness onset, symptomatology, a higher prevalence of history of childhood sexual abuse (CSA) and needs for care. Childhood sexual abuse is associated with adverse mental health consequences but as there is a gender difference in stress reactivity, there may be a differential impact of CSA on psychopathology, age of psychosis onset and needs for care in First Episode Psychosis (FEP) patients. We hypothesized that a history of abuse would be associated with lowering of age of onset, increased symptomatology and more unmet needs in women but not men. A total of 444 FEP patients have been recruited within the context of the GET UP trial. Symptomatology has been assessed using the PANSS scale, needs for care with the CAN scale and childhood abuse with the CECA-Q scale. Childhood sexual abuse was more frequent among female patients [22.6% in women vs 11.6% in men (OR = 0.45, p 

Original language	English
Pages (from-to)	164-171
Number of pages	8
Journal	Schizophrenia Research
Volume	210
DOIs	https://doi.org/10.1016/j.schres.2018.12.046
Publication status	Published - Aug 2019

Keywords

*Childhood abuse
*Childhood trauma
*FEP
*First episode psychosis
*Gender
*Physical abuse
*Psychosis
*Sexual abuse

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10.1016/j.schres.2018.12.046

https://pubmed.ncbi.nlm.nih.gov/30642687

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Comacchio, C., Howard, L. M., Bonetto, C., Lo Parrino, R., Furlato, K., Semrov, E., Preti, A., Mesiano, L., Neri, G., De Girolamo, G., de Santi, K., Miglietta, E., Tosato, S., Cristofalo, D., Lasalvia, A., Ruggeri, M., & Group, GET. UP. (2019). The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients. Schizophrenia Research, 210, 164-171. https://doi.org/10.1016/j.schres.2018.12.046

The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients. / Comacchio, Carla; Howard, Louise M; Bonetto, Chiara; Lo Parrino, Riccardo; Furlato, Karin; Semrov, Enrico; Preti, Antonio; Mesiano, Luca; Neri, Giovanni; De Girolamo, Giovanni; de Santi, Katia; Miglietta, Elisabetta; Tosato, Sarah; Cristofalo, Doriana; Lasalvia, Antonio; Ruggeri, Mirella; Group, GET UP.

In: Schizophrenia Research, Vol. 210, 08.2019, p. 164-171.

Research output: Contribution to journal › Article › peer-review

Comacchio, C, Howard, LM, Bonetto, C, Lo Parrino, R, Furlato, K, Semrov, E, Preti, A, Mesiano, L, Neri, G, De Girolamo, G, de Santi, K, Miglietta, E, Tosato, S, Cristofalo, D, Lasalvia, A, Ruggeri, M & Group, GETUP 2019, 'The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients', Schizophrenia Research, vol. 210, pp. 164-171. https://doi.org/10.1016/j.schres.2018.12.046

Comacchio, Carla ; Howard, Louise M ; Bonetto, Chiara ; Lo Parrino, Riccardo ; Furlato, Karin ; Semrov, Enrico ; Preti, Antonio ; Mesiano, Luca ; Neri, Giovanni ; De Girolamo, Giovanni ; de Santi, Katia ; Miglietta, Elisabetta ; Tosato, Sarah ; Cristofalo, Doriana ; Lasalvia, Antonio ; Ruggeri, Mirella ; Group, GET UP. / The impact of gender and childhood abuse on age of psychosis onset, psychopathology and needs for care in psychosis patients. In: Schizophrenia Research. 2019 ; Vol. 210. pp. 164-171.

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abstract = "Gender is associated with several features of psychotic disorders, including age of illness onset, symptomatology, a higher prevalence of history of childhood sexual abuse (CSA) and needs for care. Childhood sexual abuse is associated with adverse mental health consequences but as there is a gender difference in stress reactivity, there may be a differential impact of CSA on psychopathology, age of psychosis onset and needs for care in First Episode Psychosis (FEP) patients. We hypothesized that a history of abuse would be associated with lowering of age of onset, increased symptomatology and more unmet needs in women but not men. A total of 444 FEP patients have been recruited within the context of the GET UP trial. Symptomatology has been assessed using the PANSS scale, needs for care with the CAN scale and childhood abuse with the CECA-Q scale. Childhood sexual abuse was more frequent among female patients [22.6% in women vs 11.6% in men (OR = 0.45, p ",

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