TY - JOUR
T1 - The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non-obese and obese children
AU - Bona, G.
AU - Petri, A.
AU - Rapa, A.
AU - Conti, A.
AU - Sartorio, A.
PY - 1999
Y1 - 1999
N2 - OBJECTIVE: There is a lack of normal reference data on urinary GH (u- GH) excretion in children, We have investigated the impact of age, gender, pubertal development and body mass on reference values for u-GH excretion in normally growing non-obese and obese children. STUDY DESIGN: u-GH levels were evaluated in 1153 healthy normal children (aged 5-14) and in 684 obese children (body mass index, BMI:>75th). u-GH levels (ng/8 h) were determined by ELISA as the mean value of three consecutive first morning voidings. RESULTS: Reference values (5-95th centile) for u-GH excretion in obese and non-obese children of both sexes are reported. In normal prepubertal children median u-GH levels were relatively stable and superimposable in the two sexes; subsequently, u-GH levels increased, reaching a peak Value at 13 years in both sexes. Significant increments (P
AB - OBJECTIVE: There is a lack of normal reference data on urinary GH (u- GH) excretion in children, We have investigated the impact of age, gender, pubertal development and body mass on reference values for u-GH excretion in normally growing non-obese and obese children. STUDY DESIGN: u-GH levels were evaluated in 1153 healthy normal children (aged 5-14) and in 684 obese children (body mass index, BMI:>75th). u-GH levels (ng/8 h) were determined by ELISA as the mean value of three consecutive first morning voidings. RESULTS: Reference values (5-95th centile) for u-GH excretion in obese and non-obese children of both sexes are reported. In normal prepubertal children median u-GH levels were relatively stable and superimposable in the two sexes; subsequently, u-GH levels increased, reaching a peak Value at 13 years in both sexes. Significant increments (P
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U2 - 10.1046/j.1365-2265.1999.00728.x
DO - 10.1046/j.1365-2265.1999.00728.x
M3 - Article
C2 - 10468950
AN - SCOPUS:0033021007
VL - 50
SP - 775
EP - 781
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 6
ER -