TY - JOUR
T1 - The impact of healthy lifestyles on late sequelae in classical hodgkin lymphoma and diffuse large b-cell lymphoma survivors. A systematic review by the fondazione italiana linfomi.
AU - Minoia, Carla
AU - Gerardi, Chiara
AU - Allocati, Eleonora
AU - Daniele, Antonella
AU - De Sanctis, Vitaliana
AU - Bari, Alessia
AU - Guarini, Attilio
N1 - Funding Information:
Supported by Ministry of Health, Italian Government, R.C. funds 2021, to the IRCCS Istituto Tumori ?Giovanni Paolo II,? Bari-Italy (del. 153/21). We thank the BCC Credito Cooperativo di Castellana Grotte, Bari?Italy, for unconditional support to the study. The authors are grateful to the FIL researchers who performed an internal review on the manuscript. The authors also thank the Clinical Trial Office of FIL for technical support, and Rita Banzi from the Istituto di Ricerche Farmacologiche ?Mario Negri? IRCCS, Milano, Italy for the methodological supervision. Thanks to all research institutes and hospital involved. The authors thank AIL (Associazione Italiana contro leucemie, linfomi e myeloma) for the support to the ?Long-term Survivor Committee? of FIL.
Funding Information:
Funding: Supported by Ministry of Health, Italian Government, R.C. funds 2021, to the IRCCS Istituto Tumori “Giovanni Paolo II,” Bari-Italy (del. 153/21). We thank the BCC Credito Cooperativo di Castellana Grotte, Bari—Italy, for unconditional support to the study.
Publisher Copyright:
© 2021, MDPI AG. All rights reserved.
PY - 2021/6/23
Y1 - 2021/6/23
N2 - Background: In recent years, the scientific community has been paying ever more attention to the promotion of lifestyles aimed at the prevention of late toxicities related to anti-cancer treatments. Methods: Fondazione Italiana Linfomi (FIL) researchers conducted a systematic review in order to evaluate the evidence in favor of the promotion of lifestyles aimed at the prevention of the main sequelae of long-term classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) in survivors treated at adulthood with first-line or second-line therapy, including autologous stem cell transplants (ASCTs). Pubmed, Embase and Cochrane Library were searched up to December 2020. Results: Seven studies were ultimately included in this systematic review; some of them were eligible for multiple PICOS. The majority of the studies emerged from data extraction regarding cHL; less evidence resulted for DLBCL survivors. Five studies in favor of physical activity provided consistent data for a reduction of the cardiovascular risk in cHL and also in survivors who underwent ASCT. A beneficial effect of physical activity in reducing chronic fatigue was found. Being overweight was associated with a higher risk of coronary heart disease in cHL survivors in one of the two eligible studies. Studies aiming to evaluate the impact of the Mediterranean diet on late toxicities and secondary cancers were lacking. Tailored survivorship care plans (SCP) seemed to represent an optimal tool to guide the follow-up and promote healthier lifestyles in the one eligible study. Thus, promotion of healthy lifestyles and empowering of lymphoma survivors should be implemented through structured models. The study also brought to light numerous areas of future clinical research.
AB - Background: In recent years, the scientific community has been paying ever more attention to the promotion of lifestyles aimed at the prevention of late toxicities related to anti-cancer treatments. Methods: Fondazione Italiana Linfomi (FIL) researchers conducted a systematic review in order to evaluate the evidence in favor of the promotion of lifestyles aimed at the prevention of the main sequelae of long-term classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) in survivors treated at adulthood with first-line or second-line therapy, including autologous stem cell transplants (ASCTs). Pubmed, Embase and Cochrane Library were searched up to December 2020. Results: Seven studies were ultimately included in this systematic review; some of them were eligible for multiple PICOS. The majority of the studies emerged from data extraction regarding cHL; less evidence resulted for DLBCL survivors. Five studies in favor of physical activity provided consistent data for a reduction of the cardiovascular risk in cHL and also in survivors who underwent ASCT. A beneficial effect of physical activity in reducing chronic fatigue was found. Being overweight was associated with a higher risk of coronary heart disease in cHL survivors in one of the two eligible studies. Studies aiming to evaluate the impact of the Mediterranean diet on late toxicities and secondary cancers were lacking. Tailored survivorship care plans (SCP) seemed to represent an optimal tool to guide the follow-up and promote healthier lifestyles in the one eligible study. Thus, promotion of healthy lifestyles and empowering of lymphoma survivors should be implemented through structured models. The study also brought to light numerous areas of future clinical research.
KW - Classical Hodgkin lymphoma
KW - Diffuse large B-cell lymphoma
KW - Healthy lifestyle
KW - Physical exercise
KW - Quality of life
KW - Survivors
KW - Survivorship care plan
KW - Systematic review
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U2 - 10.3390/cancers13133135
DO - 10.3390/cancers13133135
M3 - Review article
AN - SCOPUS:85108275355
VL - 13
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 13
M1 - 3135
ER -