The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients

Chi Un Pae, Antonio Drago, Jung Jin Kim, Laura Mandelli, Diana De Ronchi, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review

Abstract

We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalNeuropsychobiology
Volume59
Issue number3
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Gene association
  • Heat shock proteins
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

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