The impact of HPV-specific infection in women diagnosed with atypical glandular cells: Results from the HPV-AGC study.

Giorgio Bogani, Francesco Sopracordevole, Jvan Casarin, Ciro Pinelli, Umberto Leone Roberti Maggiore, Claudia Brusadelli, Rocco Guerrisi, Antonino Ditto, Andrea Dell'Acqua, Maurizio Serati, Salvatore Lopez, Simone Ferrero, Fabio Ghezzi, Francesco Raspagliesi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To evaluate the impact of various HPV types on the risk of developing lesions of the uterus (either uterine cervix and endometrium) in women diagnosed with "atypical glandular cells" (AGC) at Pap smear. METHODS: This is a multi-institutional retrospective study. Data of women diagnosed with AGC were retrospectively reviewed. All patients included had data about HPV DNA testing and 1-year clinical follow-up. RESULTS: Overall, chart of 480 patients were evaluated. After the exclusion of 286 patients, data of 194 patients were available for the analysis. Mean age was 43.9 (±6.0) years. HPV infection was documented in 136 women (70.1 . Among HPV positive patients the risk of having/developing a lesion was 33.8 n = 46). Lesions included low- (L-SIL) and high- (H-SIL) squamous intraepithelial lesions, in situ adenocarcinoma of the uterine cervix, invasive cancer of the uterine cervix, endometrial hyperplasia and endometrial cancer in 16 (11.7 , 18 (13.2 , 6 (4.4 , 3 (2.2 , 2 (1.5 and 1 (1, respectively. Among HPV negative patients the risk of having/developing a lesion was 15.5 SIL, H-SIL, in situ adenocarcinoma, endometrial hyperplasia and endometrial cancer in 1 (1.7 , 1 (1.7 , 1 (1.7 , 3 (5.1 and 3 (5.1 , respectively. Patients diagnosed with HPV16 were at higher risk of having/developing cervical lesions in comparison to patients with other HPV infections (p textless 0.01). In comparison to other HPV types, the presence of HPV 18, 31, 33, and 45 did not increase the risk of developing a lesion over the time (p textgreater 0.2). HPV positive patients were at higher risk of being diagnosed with a cervical lesion within 6 months from detection of AGC. CONCLUSIONS: Patients diagnosed with AGC are at risk to have / developing cervical and uterine lesions. Further prospective evidence is needed.
Original languageEnglish
JournalPathology Research and Practice
Issue number11
Publication statusPublished - Nov 1 2020

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