The impact of intestinal microbiota on weight loss in Parkinson's disease patients: A pilot study

Federica Del Chierico, Paola Grassini, Andrea Quagliariello, Margherita Torti, Alessandra Russo, Sofia Reddel, Fabrizio Stocchi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is increasing evidence of the association between microbiome dysfunction and Parkinson's disease (PD). Moreover, some PD patients suffer from unintentional weight loss (WL) which may precede the motor manifestations of the disease. Materials & methods: Gut microbiota profiling by 16S rRNA gene sequencing was performed in PD patients with an unintended WL, in steady weight patients (non-WL [NWL]) and in matched normal subjects. KEGG functional predictions were carried out. Results: Microbiota profiles revealed a dissimilarity between WL and NWL. Moreover, WL pathways were characterized by fatty acid biosynthesis, while NWL by inflammation pathways. Conclusion: The gut microbiota could participate in weight alteration observed in PD by the presence of bacteria involved in weight gain and inflammation, or conversely by bacteria implicated in energy expenditure.

Original languageEnglish
Pages (from-to)1393-1404
Number of pages12
JournalFuture Microbiology
Volume15
Issue number14
DOIs
Publication statusPublished - Sep 2020

Keywords

  • inflammation
  • metabolism
  • microbiota
  • Parkinson's disease
  • weight loss

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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