TY - JOUR
T1 - The impact of ionizing irradiation on liver detoxifying enzymes. A re-investigation
AU - Bocedi, Alessio
AU - Ingrosso, Gianluca
AU - Cattani, Giada
AU - Miceli, Roberto
AU - Ponti, Elisabetta
AU - Lancia, Andrea
AU - Baldelli, Sara
AU - Guidi, Arianna
AU - Ciriolo, Maria Rosa
AU - Mattei, Maurizio
AU - Ricci, Giorgio
PY - 2019/12/1
Y1 - 2019/12/1
N2 - By looking at many studies describing the impact of ionizing irradiations in living mice on a few key detoxifying enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione transferase, we noted conflicting evidences: almost all papers finalized to demonstrate the protective effects of natural or synthetic drugs against the damage by irradiations, described also a relevant inactivation of these enzymes in the absence of these compounds. Conversely, no inactivation and even enhanced activity has been noted under similar irradiation modality in all studies supporting the “adaptive response”. Motivated by these curious discrepancies, we performed irradiation experiments on living mice, explanted mouse livers and liver homogenates observing that, in all conditions the activity of all these enzymes remained almost unchanged except for a slight increase found in explanted livers. Our results put a question about many previous scientific reports in this field.
AB - By looking at many studies describing the impact of ionizing irradiations in living mice on a few key detoxifying enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione transferase, we noted conflicting evidences: almost all papers finalized to demonstrate the protective effects of natural or synthetic drugs against the damage by irradiations, described also a relevant inactivation of these enzymes in the absence of these compounds. Conversely, no inactivation and even enhanced activity has been noted under similar irradiation modality in all studies supporting the “adaptive response”. Motivated by these curious discrepancies, we performed irradiation experiments on living mice, explanted mouse livers and liver homogenates observing that, in all conditions the activity of all these enzymes remained almost unchanged except for a slight increase found in explanted livers. Our results put a question about many previous scientific reports in this field.
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U2 - 10.1038/s41420-019-0148-8
DO - 10.1038/s41420-019-0148-8
M3 - Article
AN - SCOPUS:85061321477
VL - 5
JO - Cell Death Discovery
JF - Cell Death Discovery
SN - 2058-7716
IS - 1
M1 - 66
ER -