The impact of ionizing irradiation on liver detoxifying enzymes. A re-investigation

Alessio Bocedi, Gianluca Ingrosso, Giada Cattani, Roberto Miceli, Elisabetta Ponti, Andrea Lancia, Sara Baldelli, Arianna Guidi, Maria Rosa Ciriolo, Maurizio Mattei, Giorgio Ricci

Research output: Contribution to journalArticlepeer-review


By looking at many studies describing the impact of ionizing irradiations in living mice on a few key detoxifying enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione transferase, we noted conflicting evidences: almost all papers finalized to demonstrate the protective effects of natural or synthetic drugs against the damage by irradiations, described also a relevant inactivation of these enzymes in the absence of these compounds. Conversely, no inactivation and even enhanced activity has been noted under similar irradiation modality in all studies supporting the “adaptive response”. Motivated by these curious discrepancies, we performed irradiation experiments on living mice, explanted mouse livers and liver homogenates observing that, in all conditions the activity of all these enzymes remained almost unchanged except for a slight increase found in explanted livers. Our results put a question about many previous scientific reports in this field.

Original languageEnglish
Article number66
JournalCell Death Discovery
Issue number1
Publication statusPublished - Dec 1 2019

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research


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