The impact of microRNAs on myeloid-derived suppressor cells in cancer.

Elham baghbani, Saeed Noorolyai, Pascal H.G. Duijf, Nicola Silvestris, Saeed Kolahian, Shahryar Hashemzadeh, Amir Baghbanzadeh kojabad, Aisan FallahVazirabad, Behzad Baradaran

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammation promotes cancer development. To a large extent, this can be attributed to the recruitment of myeloid-derived suppressor cells (MDSCs) to tumors. These cells are known for establishing an immunosuppressive tumor microenvironment by suppressing T cell activities. However, MDSCs also promote metastasis and angiogenesis. Critically, as small non-coding RNAs that regulate gene expression, microRNAs (miRNAs) control MDSC activities. In this review, we discuss how miRNA networks regulate key MDSC signaling pathways, how they shape MDSC development, differentiation and activation, and how this impacts tumor development. By targeting the expression of miRNAs in MDSCs, we can alter their main signaling pathways. In turn, this can compromise their ability to promote multiple hallmarks of cancer. Therefore, this may represent a new powerful strategy for cancer immunotherapy.

Original languageEnglish
Pages (from-to)668-678
Number of pages11
JournalHuman Immunology
Volume82
Issue number9
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Cancer
  • MDSC
  • miRNA
  • Signaling pathways

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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