The impact of new technologies in cervical cancer screening: Results of the recruitment phase of a large randomised controlled trial from a public health perspective

Paolo Giorgi-Rossi, Nereo Segnan, Marco Zappa, Carlo Naldoni, Manuel Zorzi, Massimo Confortini, Monica Merito, Jack Cuzick, Guglielmo Ronco

Research output: Contribution to journalArticlepeer-review

Abstract

The decision to introduce liquid-based cytology (LBC) and HPV as screening tests involves criteria based on resource consumption. We used cross-sectional data at recruitment from the NTCC trial [ISRCTN81678807] on 28,000 women aged 35-60, randomised to receive a conventional Pap test or LBC plus HPV. We computed the resources employed to detect a CIN2+ with different screening strategies. In order to result in the same overall cost per CIN2+ detected as screening by conventional cytology, the unit cost of LBC used alone should be less than that of a conventional Pap while its unit cost may be up to 20% higher if HPV-triage for Atypical Squamous Cells of Undetermined Significance is applied together. With the same criterion the unit cost of HPV used alone may be about 20% higher than that of a Pap-test using a 1 pg/ml cut-off and over 40% higher using a 10 pg/ml cut-off. If HPV testing is applied with cytology-triage, a single HPV test may cost 20-30% more than a conventional Pap to result in the same overall cost per CIN2+ detected.

Original languageEnglish
Pages (from-to)2729-2734
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number12
DOIs
Publication statusPublished - Nov 15 2007

Keywords

  • Cancer screening
  • Cervical cancer
  • Costs
  • Health services workload
  • Human papilloma virus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'The impact of new technologies in cervical cancer screening: Results of the recruitment phase of a large randomised controlled trial from a public health perspective'. Together they form a unique fingerprint.

Cite this