Abstract

AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis.

METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region.

RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.

CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.

Original languageEnglish
Pages (from-to)6-15
Number of pages10
JournalEuropean Journal of Cancer
Volume94
DOIs
Publication statusPublished - May 2018

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Thyroid Neoplasms
Italy
Incidence
Medical Overuse
Registries
Histology
Thyroid Gland
Population
Neoplasms

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Epidemics
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Italy/epidemiology
  • Male
  • Medical Overuse
  • Middle Aged
  • Registries
  • Thyroid Neoplasms/epidemiology
  • Young Adult

Cite this

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012. / for AIRTUM working group.

In: European Journal of Cancer, Vol. 94, 05.2018, p. 6-15.

Research output: Contribution to journalArticle

@article{d76931f26b94455cac59143923d5957a,
title = "The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012",
abstract = "AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis.METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region.RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74{\%} in women (from 16.2 to 28.2/100,000) and of 90{\%} in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91{\%} in women, +120{\%} in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75{\%} of cases in women and 63{\%} in men and increased over the study period leading to overdiagnosis of 79{\%} in women and 67{\%} in men in 2008-2012. Notably, overdiagnosis was over 80{\%} among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Epidemics, Female, Humans, Incidence, Infant, Infant, Newborn, Italy/epidemiology, Male, Medical Overuse, Middle Aged, Registries, Thyroid Neoplasms/epidemiology, Young Adult",
author = "{for AIRTUM working group} and {Dal Maso}, Luigino and Chiara Panato and Silvia Franceschi and Diego Serraino and Carlotta Buzzoni and Susanna Busco and Stefano Ferretti and Antonietta Torrisi and Fabio Falcini and Manuel Zorzi and Claudia Cirilli and Walter Mazzucco and Michele Magoni and Paolo Collarile and Fabio Pannozzo and Caiazzo, {Anna Luisa} and Russo, {Antonio Giampiero} and Alessio Gili and Adele Caldarella and Roberto Zanetti and Maria Michiara and Lucia Mangone and Filiberti, {Rosa Angela} and Mario Fusco and Francesca Gasparini and Giovanna Tagliabue and Rosaria Cesaraccio and Rosario Tumino and Luciana Gatti and Francesco Tisano and Silvano Piffer and Sini, {Giovanna Maria} and Guido Mazzoleni and Stefano Rosso and Fanetti, {Anna Clara} and Salvatore Vaccarella",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "5",
doi = "10.1016/j.ejca.2018.01.083",
language = "English",
volume = "94",
pages = "6--15",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

AU - for AIRTUM working group

AU - Dal Maso, Luigino

AU - Panato, Chiara

AU - Franceschi, Silvia

AU - Serraino, Diego

AU - Buzzoni, Carlotta

AU - Busco, Susanna

AU - Ferretti, Stefano

AU - Torrisi, Antonietta

AU - Falcini, Fabio

AU - Zorzi, Manuel

AU - Cirilli, Claudia

AU - Mazzucco, Walter

AU - Magoni, Michele

AU - Collarile, Paolo

AU - Pannozzo, Fabio

AU - Caiazzo, Anna Luisa

AU - Russo, Antonio Giampiero

AU - Gili, Alessio

AU - Caldarella, Adele

AU - Zanetti, Roberto

AU - Michiara, Maria

AU - Mangone, Lucia

AU - Filiberti, Rosa Angela

AU - Fusco, Mario

AU - Gasparini, Francesca

AU - Tagliabue, Giovanna

AU - Cesaraccio, Rosaria

AU - Tumino, Rosario

AU - Gatti, Luciana

AU - Tisano, Francesco

AU - Piffer, Silvano

AU - Sini, Giovanna Maria

AU - Mazzoleni, Guido

AU - Rosso, Stefano

AU - Fanetti, Anna Clara

AU - Vaccarella, Salvatore

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis.METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region.RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.

AB - AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis.METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region.RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Epidemics

KW - Female

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Italy/epidemiology

KW - Male

KW - Medical Overuse

KW - Middle Aged

KW - Registries

KW - Thyroid Neoplasms/epidemiology

KW - Young Adult

U2 - 10.1016/j.ejca.2018.01.083

DO - 10.1016/j.ejca.2018.01.083

M3 - Article

C2 - 29502036

VL - 94

SP - 6

EP - 15

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

ER -