The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: A multi-institutional analysis of 305 cases

Mechteld C. De Jong; Hugo Marques; Bryan M. Clary; Todd W. Bauer; J. Wallis Marsh; Dario Ribero; Pietro Majno; Ioannis Hatzaras; Dustin M. Walters; Andrew S. Barbas; Raquel Mega; Richard D. Schulick; Michael A. Choti; David A. Geller; Eduardo Barroso; Gilles Mentha; Lorenzo Capussotti; Timothy M. Pawlik

doi:10.1002/cncr.27492

The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: A multi-institutional analysis of 305 cases

Mechteld C. De Jong, Hugo Marques, Bryan M. Clary, Todd W. Bauer, J. Wallis Marsh, Dario Ribero, Pietro Majno, Ioannis Hatzaras, Dustin M. Walters, Andrew S. Barbas, Raquel Mega, Richard D. Schulick, Michael A. Choti, David A. Geller, Eduardo Barroso, Gilles Mentha, Lorenzo Capussotti, Timothy M. Pawlik

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P

Original language	English
Pages (from-to)	4737-4747
Number of pages	11
Journal	Cancer
Volume	118
Issue number	19
DOIs	https://doi.org/10.1002/cncr.27492
Publication status	Published - Oct 1 2012

Fingerprint

Keywords

cholangiocarcinoma
hilar
outcome
portal vein

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

De Jong, M. C., Marques, H., Clary, B. M., Bauer, T. W., Marsh, J. W., Ribero, D., Majno, P., Hatzaras, I., Walters, D. M., Barbas, A. S., Mega, R., Schulick, R. D., Choti, M. A., Geller, D. A., Barroso, E., Mentha, G., Capussotti, L., & Pawlik, T. M. (2012). The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: A multi-institutional analysis of 305 cases. Cancer, 118(19), 4737-4747. https://doi.org/10.1002/cncr.27492

The impact of portal vein resection on outcomes for hilar cholangiocarcinoma : A multi-institutional analysis of 305 cases. / De Jong, Mechteld C.; Marques, Hugo; Clary, Bryan M.; Bauer, Todd W.; Marsh, J. Wallis; Ribero, Dario; Majno, Pietro; Hatzaras, Ioannis; Walters, Dustin M.; Barbas, Andrew S.; Mega, Raquel; Schulick, Richard D.; Choti, Michael A.; Geller, David A.; Barroso, Eduardo; Mentha, Gilles; Capussotti, Lorenzo; Pawlik, Timothy M.

In: Cancer, Vol. 118, No. 19, 01.10.2012, p. 4737-4747.

Research output: Contribution to journal › Article

De Jong, MC, Marques, H, Clary, BM, Bauer, TW, Marsh, JW, Ribero, D, Majno, P, Hatzaras, I, Walters, DM, Barbas, AS, Mega, R, Schulick, RD, Choti, MA, Geller, DA, Barroso, E, Mentha, G, Capussotti, L & Pawlik, TM 2012, 'The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: A multi-institutional analysis of 305 cases', Cancer, vol. 118, no. 19, pp. 4737-4747. https://doi.org/10.1002/cncr.27492

De Jong, Mechteld C. ; Marques, Hugo ; Clary, Bryan M. ; Bauer, Todd W. ; Marsh, J. Wallis ; Ribero, Dario ; Majno, Pietro ; Hatzaras, Ioannis ; Walters, Dustin M. ; Barbas, Andrew S. ; Mega, Raquel ; Schulick, Richard D. ; Choti, Michael A. ; Geller, David A. ; Barroso, Eduardo ; Mentha, Gilles ; Capussotti, Lorenzo ; Pawlik, Timothy M. / The impact of portal vein resection on outcomes for hilar cholangiocarcinoma : A multi-institutional analysis of 305 cases. In: Cancer. 2012 ; Vol. 118, No. 19. pp. 4737-4747.

@article{19df1b4118e54953949fc6797cafa291,

title = "The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: A multi-institutional analysis of 305 cases",

abstract = "BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P ",

keywords = "cholangiocarcinoma, hilar, outcome, portal vein",

author = "{De Jong}, {Mechteld C.} and Hugo Marques and Clary, {Bryan M.} and Bauer, {Todd W.} and Marsh, {J. Wallis} and Dario Ribero and Pietro Majno and Ioannis Hatzaras and Walters, {Dustin M.} and Barbas, {Andrew S.} and Raquel Mega and Schulick, {Richard D.} and Choti, {Michael A.} and Geller, {David A.} and Eduardo Barroso and Gilles Mentha and Lorenzo Capussotti and Pawlik, {Timothy M.}",

year = "2012",

month = oct

day = "1",

doi = "10.1002/cncr.27492",

language = "English",

volume = "118",

pages = "4737--4747",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "19",

}

TY - JOUR

T1 - The impact of portal vein resection on outcomes for hilar cholangiocarcinoma

T2 - A multi-institutional analysis of 305 cases

AU - De Jong, Mechteld C.

AU - Marques, Hugo

AU - Clary, Bryan M.

AU - Bauer, Todd W.

AU - Marsh, J. Wallis

AU - Ribero, Dario

AU - Majno, Pietro

AU - Hatzaras, Ioannis

AU - Walters, Dustin M.

AU - Barbas, Andrew S.

AU - Mega, Raquel

AU - Schulick, Richard D.

AU - Choti, Michael A.

AU - Geller, David A.

AU - Barroso, Eduardo

AU - Mentha, Gilles

AU - Capussotti, Lorenzo

AU - Pawlik, Timothy M.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P

AB - BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P

KW - cholangiocarcinoma

KW - hilar

KW - outcome

KW - portal vein

UR - http://www.scopus.com/inward/record.url?scp=84866501937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866501937&partnerID=8YFLogxK

U2 - 10.1002/cncr.27492

DO - 10.1002/cncr.27492

M3 - Article

C2 - 22415526

AN - SCOPUS:84866501937

VL - 118

SP - 4737

EP - 4747

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 19

ER -

Access to Document

10.1002/cncr.27492