Abstract
BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P
| Original language | English |
|---|---|
| Pages (from-to) | 4737-4747 |
| Number of pages | 11 |
| Journal | Cancer |
| Volume | 118 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2012 |
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Keywords
- cholangiocarcinoma
- hilar
- outcome
- portal vein
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
The impact of portal vein resection on outcomes for hilar cholangiocarcinoma : A multi-institutional analysis of 305 cases. / De Jong, Mechteld C.; Marques, Hugo; Clary, Bryan M.; Bauer, Todd W.; Marsh, J. Wallis; Ribero, Dario; Majno, Pietro; Hatzaras, Ioannis; Walters, Dustin M.; Barbas, Andrew S.; Mega, Raquel; Schulick, Richard D.; Choti, Michael A.; Geller, David A.; Barroso, Eduardo; Mentha, Gilles; Capussotti, Lorenzo; Pawlik, Timothy M.
In: Cancer, Vol. 118, No. 19, 01.10.2012, p. 4737-4747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of portal vein resection on outcomes for hilar cholangiocarcinoma
T2 - A multi-institutional analysis of 305 cases
AU - De Jong, Mechteld C.
AU - Marques, Hugo
AU - Clary, Bryan M.
AU - Bauer, Todd W.
AU - Marsh, J. Wallis
AU - Ribero, Dario
AU - Majno, Pietro
AU - Hatzaras, Ioannis
AU - Walters, Dustin M.
AU - Barbas, Andrew S.
AU - Mega, Raquel
AU - Schulick, Richard D.
AU - Choti, Michael A.
AU - Geller, David A.
AU - Barroso, Eduardo
AU - Mentha, Gilles
AU - Capussotti, Lorenzo
AU - Pawlik, Timothy M.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P
AB - BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival. METHODS: Three hundred five patients who underwent curative-intent surgery for hilar cholangiocarcinoma between 1984 and 2010 were identified from an international, multi-institutional database. Clinicopathologic data were evaluated using univariate and multivariate analyses. RESULTS: Most patients had hilar cholangiocarcinoma with tumors classified as T3/T4 (51.1%) and Bismuth-Corlette type II/III (60.9%). Resection involved extrahepatic bile duct resection (EHBR) alone (26.6%); or hepatectomy and EHBR without PVR (56.7%); or combined hepatectomy, EHBR, and PVR (16.7%). Negative resection (R0) margin status was higher among the patients who underwent hepatectomy plus EHBR (without PVR, 64.2%; with PVR, 66.7%) versus EHBR alone (54.3%; P
KW - cholangiocarcinoma
KW - hilar
KW - outcome
KW - portal vein
UR - http://www.scopus.com/inward/record.url?scp=84866501937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866501937&partnerID=8YFLogxK
U2 - 10.1002/cncr.27492
DO - 10.1002/cncr.27492
M3 - Article
C2 - 22415526
AN - SCOPUS:84866501937
VL - 118
SP - 4737
EP - 4747
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 19
ER -