The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury

R. Formisano, C. Barba, M. G. Buzzi, J. Newcomb-Fernandez, F. Menniti-Ippolito, R. Zafonte, V. Vinicola, F. Spanedda

Research output: Contribution to journalArticlepeer-review


Aim: To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment. Methods: Two populations were studied: 55 patients retrospectively and 82 subjects prospectively. Results: Ten patients (18%) in the first population showed late PTE. Although the incidence was lower in patients who did not receive prophylactic treatment, the difference between the treated and the non-treated group was not statistically significant. Sixty-nine patients in the second group (84%) had prophylactic treatment. Twenty-seven patients (39%) suffered from late PTE during the 2-year follow-up period and 17 of them (63%) showed EEG epileptic abnormalities. No patient who did not receive preventive therapy suffered from late PTE during the observation period. Conclusions: Due to the negative cognitive effects of anti-epileptic drugs, the preliminary results are of considerable interest for the rehabilitation of patients with very severe TBI.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalBrain Injury
Issue number5
Publication statusPublished - 2007


  • Cognitive functioning
  • Late post-traumatic epilepsy
  • Prophylactic anti-epileptic treatment
  • Severe traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology


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