The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis

Giovanni Palladini, Paolo Milani, Andrea Foli, Marco Basset, Francesca Russo, Tiziana Bosoni, Laura Pirolini, Veronica Valentini, Giovanni Ferraro, Francesca Lavatelli, Alessandra Barassi, Riccardo Albertini, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The measurement of circulating free light chains (FLC) is of utmost importance in immunoglobulin light chain (AL) amyloidosis, being a fundamental part of the diagnostic workup, prognostic stratification and assessment of response to therapy. Renal failure is a common feature of AL amyloidosis and can considerably affect the concentration of FLC. Methods: We assessed the impact of renal failure on the clinical performance of the Freelite assay in 982 consecutive, newly diagnosed patients with AL amyloidosis, 822 with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, and 160 with eGFR 2. Results: The diagnostic sensitivity of the κ/λ FLC ratio was lower for λ amyloidogenic FLC in patients with renal failure (81% vs. 60%, p

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • amyloidosis
  • free light chains
  • renal failure

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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