TY - JOUR
T1 - The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis
AU - Palladini, Giovanni
AU - Milani, Paolo
AU - Foli, Andrea
AU - Basset, Marco
AU - Russo, Francesca
AU - Bosoni, Tiziana
AU - Pirolini, Laura
AU - Valentini, Veronica
AU - Ferraro, Giovanni
AU - Lavatelli, Francesca
AU - Barassi, Alessandra
AU - Albertini, Riccardo
AU - Merlini, Giampaolo
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background: The measurement of circulating free light chains (FLC) is of utmost importance in immunoglobulin light chain (AL) amyloidosis, being a fundamental part of the diagnostic workup, prognostic stratification and assessment of response to therapy. Renal failure is a common feature of AL amyloidosis and can considerably affect the concentration of FLC. Methods: We assessed the impact of renal failure on the clinical performance of the Freelite assay in 982 consecutive, newly diagnosed patients with AL amyloidosis, 822 with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, and 160 with eGFR 2. Results: The diagnostic sensitivity of the κ/λ FLC ratio was lower for λ amyloidogenic FLC in patients with renal failure (81% vs. 60%, p
AB - Background: The measurement of circulating free light chains (FLC) is of utmost importance in immunoglobulin light chain (AL) amyloidosis, being a fundamental part of the diagnostic workup, prognostic stratification and assessment of response to therapy. Renal failure is a common feature of AL amyloidosis and can considerably affect the concentration of FLC. Methods: We assessed the impact of renal failure on the clinical performance of the Freelite assay in 982 consecutive, newly diagnosed patients with AL amyloidosis, 822 with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, and 160 with eGFR 2. Results: The diagnostic sensitivity of the κ/λ FLC ratio was lower for λ amyloidogenic FLC in patients with renal failure (81% vs. 60%, p
KW - amyloidosis
KW - free light chains
KW - renal failure
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U2 - 10.1515/cclm-2015-0985
DO - 10.1515/cclm-2015-0985
M3 - Article
AN - SCOPUS:84969884421
VL - 54
SP - 939
EP - 945
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 6
ER -