The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis

Giovanni Palladini; Paolo Milani; Andrea Foli; Marco Basset; Francesca Russo; Tiziana Bosoni; Laura Pirolini; Veronica Valentini; Giovanni Ferraro; Francesca Lavatelli; Alessandra Barassi; Riccardo Albertini; Giampaolo Merlini

doi:10.1515/cclm-2015-0985

The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis

Giovanni Palladini, Paolo Milani, Andrea Foli, Marco Basset, Francesca Russo, Tiziana Bosoni, Laura Pirolini, Veronica Valentini, Giovanni Ferraro, Francesca Lavatelli, Alessandra Barassi, Riccardo Albertini, Giampaolo Merlini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The measurement of circulating free light chains (FLC) is of utmost importance in immunoglobulin light chain (AL) amyloidosis, being a fundamental part of the diagnostic workup, prognostic stratification and assessment of response to therapy. Renal failure is a common feature of AL amyloidosis and can considerably affect the concentration of FLC. Methods: We assessed the impact of renal failure on the clinical performance of the Freelite assay in 982 consecutive, newly diagnosed patients with AL amyloidosis, 822 with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m², and 160 with eGFR 2. Results: The diagnostic sensitivity of the κ/λ FLC ratio was lower for λ amyloidogenic FLC in patients with renal failure (81% vs. 60%, p

Original language	English
Pages (from-to)	939-945
Number of pages	7
Journal	Clinical Chemistry and Laboratory Medicine
Volume	54
Issue number	6
DOIs	https://doi.org/10.1515/cclm-2015-0985
Publication status	Published - Jun 1 2016

Keywords

amyloidosis
free light chains
renal failure

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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Palladini, G., Milani, P., Foli, A., Basset, M., Russo, F., Bosoni, T., Pirolini, L., Valentini, V., Ferraro, G., Lavatelli, F., Barassi, A., Albertini, R., & Merlini, G. (2016). The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis. Clinical Chemistry and Laboratory Medicine, 54(6), 939-945. https://doi.org/10.1515/cclm-2015-0985

The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis. / Palladini, Giovanni; Milani, Paolo; Foli, Andrea; Basset, Marco; Russo, Francesca; Bosoni, Tiziana; Pirolini, Laura; Valentini, Veronica; Ferraro, Giovanni; Lavatelli, Francesca; Barassi, Alessandra; Albertini, Riccardo ; Merlini, Giampaolo.

In: Clinical Chemistry and Laboratory Medicine, Vol. 54, No. 6, 01.06.2016, p. 939-945.

Research output: Contribution to journal › Article › peer-review

Palladini, G, Milani, P, Foli, A, Basset, M, Russo, F, Bosoni, T, Pirolini, L, Valentini, V, Ferraro, G, Lavatelli, F, Barassi, A, Albertini, R & Merlini, G 2016, 'The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis', Clinical Chemistry and Laboratory Medicine, vol. 54, no. 6, pp. 939-945. https://doi.org/10.1515/cclm-2015-0985

Palladini, Giovanni ; Milani, Paolo ; Foli, Andrea ; Basset, Marco ; Russo, Francesca ; Bosoni, Tiziana ; Pirolini, Laura ; Valentini, Veronica ; Ferraro, Giovanni ; Lavatelli, Francesca ; Barassi, Alessandra ; Albertini, Riccardo ; Merlini, Giampaolo. / The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis. In: Clinical Chemistry and Laboratory Medicine. 2016 ; Vol. 54, No. 6. pp. 939-945.

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abstract = "Background: The measurement of circulating free light chains (FLC) is of utmost importance in immunoglobulin light chain (AL) amyloidosis, being a fundamental part of the diagnostic workup, prognostic stratification and assessment of response to therapy. Renal failure is a common feature of AL amyloidosis and can considerably affect the concentration of FLC. Methods: We assessed the impact of renal failure on the clinical performance of the Freelite assay in 982 consecutive, newly diagnosed patients with AL amyloidosis, 822 with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, and 160 with eGFR 2. Results: The diagnostic sensitivity of the κ/λ FLC ratio was lower for λ amyloidogenic FLC in patients with renal failure (81% vs. 60%, p",

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AU - Bosoni, Tiziana

AU - Pirolini, Laura

AU - Valentini, Veronica

AU - Ferraro, Giovanni

AU - Lavatelli, Francesca

AU - Barassi, Alessandra

AU - Albertini, Riccardo

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